2004
Randomized, Controlled Dose-Ranging Study of the Selective Adenosine A2A Receptor Agonist Binodenoson for Pharmacological Stress as an Adjunct to Myocardial Perfusion Imaging
Udelson J, Heller G, Wackers F, Chai A, Hinchman D, Coleman P, Dilsizian V, DiCarli M, Hachamovitch R, Johnson J, Barrett R, Gibbons R. Randomized, Controlled Dose-Ranging Study of the Selective Adenosine A2A Receptor Agonist Binodenoson for Pharmacological Stress as an Adjunct to Myocardial Perfusion Imaging. Circulation 2004, 109: 457-464. PMID: 14734517, DOI: 10.1161/01.cir.0000114523.03312.7d.Peer-Reviewed Original ResearchConceptsReversible perfusion defectsDose-related reductionAdenosine receptor stimulationSide effectsPharmacological stressPerfusion defectsReceptor stimulationFrequent side effectsSubjective side effectsDose-Ranging StudyMyocardial perfusion imagingAdenosine A2A receptorsSingle photon emissionChest painCoronary vasodilationCrossover trialBinodenosonA2A receptorsPerfusion imagingSelective agonismRandom orderSeverityKappa valuesSimilar degreePhoton emission
2002
Pharmacologic stress perfusion imaging with adenosine: Role of simultaneous low-level treadmill exercise
Samady H, Wackers FJ, Joska TM, Zaret BL, Jain D. Pharmacologic stress perfusion imaging with adenosine: Role of simultaneous low-level treadmill exercise. Journal Of Nuclear Cardiology 2002, 9: 188-196. PMID: 11986564, DOI: 10.1067/mnc.2002.119973.Peer-Reviewed Original ResearchConceptsLow-level treadmill exerciseMyocardial perfusion imagingTreadmill exerciseElectrocardiographic changesAdverse effectsAdenosine myocardial perfusion imagingSestamibi single-photon emissionPharmacologic stress myocardial perfusion imagingStress myocardial perfusion imagingIschemic electrocardiographic changesLow-level exerciseMore adverse effectsUnfavorable side effectsSingle photon emissionAdenosine studyAdenosine TcMore patientsMyocardial ischemiaHemodynamic responseStress perfusionSide effectsPerfusion imagingTracer uptakePatientsMPI studiesCorrelation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia.
Shi CQ, Young LH, Daher E, DiBella EV, Liu YH, Heller EN, Zoghbi S, Wackers FJ, Soufer R, Sinusas AJ. Correlation of myocardial p-(123)I-iodophenylpentadecanoic acid retention with (18)F-FDG accumulation during experimental low-flow ischemia. Journal Of Nuclear Medicine 2002, 43: 421-31. PMID: 11884504.Peer-Reviewed Original Research
2001
Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center
Abbott B, Abdel-Aziz I, Nagula S, Monico E, Schriver J, Wackers F. Selective use of single-photon emission computed tomography myocardial perfusion imaging in a chest pain center. The American Journal Of Cardiology 2001, 87: 1351-1355. PMID: 11397352, DOI: 10.1016/s0002-9149(01)01551-x.Peer-Reviewed Original ResearchConceptsChest pain centerChest pain patientsCoronary artery diseasePain patientsSingle photon emissionChest painPain centerArtery diseaseMyocardial infarctionEmergency department chest pain centersEmergency department chest pain patientsTomography myocardial perfusion imagingTomography myocardial perfusionAcute myocardial infarctionMyocardial perfusion imagingSelective useCPC patientsNonischemic electrocardiogramHospital dischargeAppropriate patientsHospital admissionFinal diagnosisMyocardial perfusionPatientsPerfusion imaging
2000
Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography
Vallejo E, Dione D, Sinusas A, Wackers F. Assessment of left ventricular ejection fraction with quantitative gated SPECT: Accuracy and correlation with first-pass radionuclide angiography. Journal Of Nuclear Cardiology 2000, 7: 461-470. PMID: 11083195, DOI: 10.1067/mnc.2000.107820.Peer-Reviewed Original ResearchConceptsVentricular ejection fractionEjection fractionPatient studiesLeft ventricular ejection fractionExtracardiac activityFirst-pass radionuclide angiographyLarger end-diastolic volumeStress-induced ischemiaEnd-diastolic volumeQuantitative gated SPECTSingle photon emissionAbnormal LVEFNormal LVEFRadionuclide angiographyDiastolic volumeLVEFPerfusion defectsLVEF valuesSame patientHeart sizeLeft ventricleGated SPECTSPECT studiesQGSMean rest
1999
Can acute rest imaging shorten evaluation in chest pain centers?
Wackers F. Can acute rest imaging shorten evaluation in chest pain centers? Journal Of Nuclear Cardiology 1999, 6: 676-678. PMID: 10608597, DOI: 10.1016/s1071-3581(99)90106-x.Peer-Reviewed Original ResearchQuantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method
Liu Y, Sinusas A, DeMan P, Zaret B, Wackers F. Quantification of SPECT myocardial perfusion images: Methodology and validation of the Yale-CQ method. Journal Of Nuclear Cardiology 1999, 6: 190-203. PMID: 10327104, DOI: 10.1016/s1071-3581(99)90080-6.Peer-Reviewed Original Research
1998
Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging.
Wu JC, Yun JJ, Heller EN, Dione DP, DeMan P, Liu YH, Zaret BL, Wackers FJ, Sinusas AJ. Limitations of dobutamine for enhancing flow heterogeneity in the presence of single coronary stenosis: implications for technetium-99m-sestamibi imaging. Journal Of Nuclear Medicine 1998, 39: 417-25. PMID: 9529285.Peer-Reviewed Original ResearchConceptsSingle-vessel stenosisMyocardial blood flowDobutamine stressCoronary stenosisTechnetium-99mBlood flowLeft circumflex artery stenosisCircumflex artery stenosisFlow deficitsSingle coronary stenosisCoronary artery diseaseRate-pressure productRegional myocardial blood flowLeft ventricular pressurePeak dobutamine stressOpen-chest dogsNonischemic flowArtery diseaseArtery stenosisPeak dobutamineSestamibi activitySevere stenosisVentricular pressureSestamibi imagingIschemic zone
1997
Myocardial perfusion defects in left bundle branch block: True or false? Fact or artifact?
Wackers F. Myocardial perfusion defects in left bundle branch block: True or false? Fact or artifact? Journal Of Nuclear Cardiology 1997, 4: 550-552. PMID: 9456196, DOI: 10.1016/s1071-3581(97)90014-3.Peer-Reviewed Original ResearchRelationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease
Gradel C, Jain D, Batsford W, Wackers F, Zaret B. Relationship of scar and ischemia to the results of programmed electrophysiological stimulation in patients with coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 379-386. PMID: 9362014, DOI: 10.1016/s1071-3581(97)90029-5.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingSustained ventricular tachycardiaPerfusion defect sizeVentricular tachycardiaElectrophysiological studiesArtery diseaseIndependent predictorsMultivariate analysisChronic coronary artery diseaseLeft ventricular ejection fractionSustained monomorphic ventricular tachycardiaGlobal left ventricular functionVentricular ejection fractionLeft ventricular functionPrevious myocardial infarctionMonomorphic ventricular tachycardiaBest independent predictorSize of ischemiaAdditional ischemiaArrhythmia historyInducible patientsNoninducible patientsSize of scarClinical predictors
1996
Are separate normal data files required for quantitative pharmacologic stress radionuclide myocardial perfusion imaging?
Wackers F. Are separate normal data files required for quantitative pharmacologic stress radionuclide myocardial perfusion imaging? Journal Of Nuclear Cardiology 1996, 3: s31-s40. PMID: 8989685, DOI: 10.1016/s1071-3581(96)90206-8.Peer-Reviewed Original ResearchQuantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model
Liu Y, Sinusas A, Shi C, Shen M, Dione D, Heller E, Wackers F. Quantification of technetium 99m-labeled sestamibi single-photon emission computed tomography based on mean counts improves accuracy for assessment of relative regional myocardial blood flow: Experimental validation in a canine model. Journal Of Nuclear Cardiology 1996, 3: 312-320. PMID: 8799250, DOI: 10.1016/s1071-3581(96)90091-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCoronary CirculationDogsHeartTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsMyocardial blood flowRelative blood flowRelative myocardial blood flowRegional myocardial blood flowCoronary artery occlusionBlood flowSingle photon emissionArtery occlusionCanine modelShort-axis slicesEx vivoSestamibi single-photon emissionMyocardial countsFlow deficitsMyocardial count densityNormal blood flowMean countsRegional myocardial perfusionCount profilesMIBI uptakeMIBI SPECTSestamibi SPECTMyocardial perfusionCircumferential count profilesRelative regional myocardial blood flow
1995
Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia.
Shi CQ, Sinusas AJ, Dione DP, Singer MJ, Young LH, Heller EN, Rinker BD, Wackers FJ, Zaret BL. Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia. Journal Of Nuclear Medicine 1995, 36: 1078-86. PMID: 7769431.Peer-Reviewed Original ResearchConceptsIschemic regionMyocardial ischemiaBlood flowEx vivo SPECTRegional myocardial blood flowPartial coronary occlusionMicrosphere blood flowMyocardial blood flowOpen-chest canine modelVivo SPECT imagesSPECT imagesVivo planarCentral ischemic regionCoronary occlusionDemand ischemiaBMS181321Technetium-99mIntravenous injectionLiver ratioMyocardial imagingCanine modelPositive imagingHepatic clearanceLiver activityArterial samplingTomographic and planar quantitation of perfusion defects on technetium 99m-labeled sestamibi scans: Evaluation in patients treated with thrombolytic therapy for acute myocardial infarction
Mortelmans L, Wackers F, Nuyts J, Schey I, Brzostek T, Schiepers C, Lesaffre E, Suetens P, Verbruggen A, Van de Werf F. Tomographic and planar quantitation of perfusion defects on technetium 99m-labeled sestamibi scans: Evaluation in patients treated with thrombolytic therapy for acute myocardial infarction. Journal Of Nuclear Cardiology 1995, 2: 133-143. PMID: 9420778, DOI: 10.1016/s1071-3581(95)80024-7.Peer-Reviewed Original Research
1994
Science, art, and artifacts: How important is quantification for the practicing physician interpreting myocardial perfusion studies?
Wackers F. Science, art, and artifacts: How important is quantification for the practicing physician interpreting myocardial perfusion studies? Journal Of Nuclear Cardiology 1994, 1: s109-s117. PMID: 9420736, DOI: 10.1007/bf03032556.Peer-Reviewed Original ResearchExercise myocardial perfusion imaging.
Wackers F. Exercise myocardial perfusion imaging. Journal Of Nuclear Medicine 1994, 35: 726-9. PMID: 8151402.Peer-Reviewed Original ResearchMeSH KeywordsCoronary CirculationCoronary DiseaseElectrocardiographyExercise TestHeartHumansSurvival RateTomography, Emission-Computed, Single-PhotonTechnetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia.
Sinusas AJ, Shi Q, Saltzberg MT, Vitols P, Jain D, Wackers FJ, Zaret BL. Technetium-99m-tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. Journal Of Nuclear Medicine 1994, 35: 664-71. PMID: 8151391.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAnimalsCoronary CirculationDogsHeartMyocardial IschemiaOrganophosphorus CompoundsOrganotechnetium CompoundsRadionuclide ImagingConceptsTechnetium-99mCanine modelPerfusion tracerMicrosphere flowCoronary artery occlusionInitial myocardial uptakeIntact canine modelOpen-chest dogsMyocardial perfusion imagingMyocardial blood flowDynamic planar imagingArtery occlusionPharmacological vasodilatationPharmacological stressMyocardial perfusion tracersMyocardial uptakeRadiotracer injectionBlood flowMyocardial perfusionPerfusion imagingArterial samplingMyocardial flowBackground activity ratioTetrofosminIschemia
1993
Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size.
Sinusas AJ, Shi Q, Vitols PJ, Fetterman RC, Maniawski P, Zaret BL, Wackers FJ. Impact of regional ventricular function, geometry, and dobutamine stress on quantitative 99mTc-sestamibi defect size. Circulation 1993, 88: 2224-2234. PMID: 8222117, DOI: 10.1161/01.cir.88.5.2224.Peer-Reviewed Original ResearchConceptsHours of reperfusionDobutamine stressMyocardial thickeningVentricular geometryDefect magnitudeCoronary artery occlusionLeft ventricular geometryOpen-chest dogsRegional ventricular functionCircumferential profile analysisDefect sizeMIBI defectsArtery occlusionMyocardial salvageVentricular functionVentricular sizePharmacological stressNonviable myocardiumES imagesMyocardial perfusionInfarcted dogsRegional functionReperfusionRisk areasDogs
1991
Adenosine or dipyridamole: Which is preferred for myocardial perfusion imaging?
Wackers F. Adenosine or dipyridamole: Which is preferred for myocardial perfusion imaging? Journal Of The American College Of Cardiology 1991, 17: 1295-1296. PMID: 2016446, DOI: 10.1016/s0735-1097(10)80138-x.Peer-Reviewed Original Research
1990
Serial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction.
Pellikka P, Behrenbeck T, Verani M, Mahmarian J, Wackers F, Gibbons R. Serial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction. Journal Of Nuclear Medicine 1990, 31: 1269-75. PMID: 2143527.Peer-Reviewed Original ResearchConceptsReperfusion therapyMyocardial infarctionTc-sestamibiAcute reperfusion therapyFirst myocardial infarctionSuccessful reperfusionTomographic myocardial perfusion imagesSerial changesHypoperfused myocardiumMean decreaseFinal studyMyocardial perfusionPatientsSignificant improvementMyocardial perfusion imagesSecond studyTherapyPerfusion imagesReperfusionInfarctionPerfusionFurther decreaseHrTomographic imagingImaging