2012
Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study
Tandon S, Wackers F, Inzucchi SE, Bansal S, Staib LH, Chyun DA, Davey JA, Young LH. Gender-based divergence of cardiovascular outcomes in asymptomatic patients with type 2 diabetes: Results from the DIAD study. Diabetes And Vascular Disease Research 2012, 9: 124-130. PMID: 22228772, DOI: 10.1177/1479164111431470.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsymptomatic DiseasesCanadaCardiovascular DiseasesDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHumansIncidenceKaplan-Meier EstimateMaleMass ScreeningMiddle AgedMyocardial Perfusion ImagingPredictive Value of TestsPrognosisProspective StudiesRisk AssessmentRisk FactorsSex FactorsTime FactorsUnited StatesConceptsType 2 diabetesMyocardial perfusion imagingCardiovascular outcomesStress myocardial perfusion imagingAsymptomatic Diabetics (DIAD) studyBetter cardiac outcomesHigh-risk womenCoronary artery diseaseHigh-risk menDetection of ischemiaMPI abnormalitiesAsymptomatic patientsAsymptomatic menCardiac eventsCardiac outcomesArtery diseaseAsymptomatic womenAbnormal screeningDiabetic studyPerfusion imagingDIAD studyWomenMenDiabetesOutcomes
2008
Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
Chia S, Nagurney J, Brown D, Raffel O, Bamberg F, Senatore F, Wackers F, Jang I. Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction. The American Journal Of Cardiology 2008, 103: 333-337. PMID: 19166685, DOI: 10.1016/j.amjcard.2008.09.085.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionLeft ventricular ejection fractionPrimary PCIST-segment elevation myocardial infarctionElevation myocardial infarctionLarger infarct sizePercutaneous coronary interventionInfarct sizeNeutrophil countMyocardial infarctionElevated leukocytesLeukocyte countCardiac eventsCoronary interventionFirst ST-segment elevation myocardial infarctionAcute Myocardial Infarction StudyST-elevation myocardial infarctionAssociation of leukocytesComposite cardiac eventsIntracellular calcium modulatorsLeft Ventricular SalvageAdverse cardiac eventsElevated leukocyte countPlacebo-controlled trialMyocardial Infarction StudyImaging Highlights From the European Society of Cardiology, American Society of Nuclear Cardiology, and Heart Failure Society of America
Knuuti J, Poldermans D, Udelson J, Wackers F, Bax J. Imaging Highlights From the European Society of Cardiology, American Society of Nuclear Cardiology, and Heart Failure Society of America. JACC Cardiovascular Imaging 2008, 1: 119-128. PMID: 19356415, DOI: 10.1016/j.jcmg.2007.10.012.Peer-Reviewed Original Research
2006
Screening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: Combined use of stress myocardial perfusion imaging and coronary calcium scoring
Scholte A, Bax J, Wackers F. Screening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: Combined use of stress myocardial perfusion imaging and coronary calcium scoring. Journal Of Nuclear Cardiology 2006, 13: 11-18. PMID: 16464712, DOI: 10.1016/j.nuclcard.2005.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCalcinosisComorbidityCoronary Artery DiseaseDiabetes Mellitus, Type 2Diagnosis, Computer-AssistedExercise TestHumansIncidenceMass ScreeningPrognosisRadionuclide ImagingReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificitySurvival RateVentricular Dysfunction, LeftConceptsSilent coronary artery diseaseCoronary artery diseaseCoronary calcium scoringType 2 diabetes mellitusMyocardial perfusion imagingArtery diseaseDiabetes mellitusCalcium scoringPerfusion imagingAsymptomatic individualsStress myocardial perfusion imagingRadionuclide myocardial perfusion imagingEarly appropriate treatmentRecent prospective studiesRates of morbidityAsymptomatic patientsCardiovascular complicationsProspective studyOverall prevalenceClinical combinationAppropriate treatmentClinical investigationMellitusClinical importanceDisease
2005
Clinical validation of SPECT attenuation correction using x-ray computed tomography–derived attenuation maps: Multicenter clinical trial with angiographic correlation
Masood Y, Liu Y, DePuey G, Taillefer R, Araujo LI, Allen S, Delbeke D, Anstett F, Peretz A, Zito M, Tsatkin V, Wackers FJ. Clinical validation of SPECT attenuation correction using x-ray computed tomography–derived attenuation maps: Multicenter clinical trial with angiographic correlation. Journal Of Nuclear Cardiology 2005, 12: 676-686. PMID: 16344230, DOI: 10.1016/j.nuclcard.2005.08.006.Peer-Reviewed Original Research
2003
Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging
Abbott B, Afshar M, Berger A, Wackers F. Prognostic significance of ischemic electrocardiographic changes during adenosine infusion in patients with normal myocardial perfusion imaging. Journal Of Nuclear Cardiology 2003, 10: 9-16. PMID: 12569326, DOI: 10.1067/mnc.2002.127625.Peer-Reviewed Original ResearchConceptsNormal myocardial perfusion imagingAdenosine myocardial perfusion imagingST-segment depressionMyocardial perfusion imagingIschemic ECG changesCardiac eventsECG changesAdenosine infusionCardiac deathPrognostic significanceECG groupNormal myocardial perfusion imagesBaseline electrocardiographic abnormalitiesAdverse cardiac eventsIschemic electrocardiographic changesNonfatal myocardial infarctionSubsequent cardiac eventsFuture cardiac eventsNormal myocardial perfusionSex-matched groupPerfusion imagesECG evidenceElectrocardiographic abnormalitiesIndependent predictorsElectrocardiographic changes
2001
Dobutamine-induced augmentation of left ventricular ejection fraction predicts survival of heart failure patients with severe non-ischaemic cardiomyopathy
Ramahi T, Longo M, Cadariu A, Rohlfs K, Slade M, Carolan S, Vallejo E, Wackers F. Dobutamine-induced augmentation of left ventricular ejection fraction predicts survival of heart failure patients with severe non-ischaemic cardiomyopathy. European Heart Journal 2001, 22: 849-856. PMID: 11350094, DOI: 10.1053/euhj.2001.2654.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionTransplant-free survivalEjection fractionHeart failureVentricular end-diastolic volume indexOverall transplant-free survivalPeak exercise oxygen consumptionSevere non-ischaemic cardiomyopathyEnd-diastolic volume indexFunctional classStrongest prognostic variableChronic heart failureHeart failure patientsPrognosis of patientsNon-ischemic cardiomyopathyExercise oxygen consumptionEquilibrium radionuclide ventriculographyVentriculographic variablesExercise capacityFailure patientsPrognostic valueRadionuclide ventriculographyIntravenous infusionDeltaLVEF
1996
Distortion of the Terminal Portion of the QRS on the Admission Electrocardiogram in Acute Myocardial Infarction and Correlation With Infarct Size and Long-Term Prognosis (Thrombolysis In Myocardial Infarction 4 Trial)**This study was supported in part by a grant from SmithKline Beecham, Philadelphia, Pennsylvania.
Birnbaum Y, Kloner R, Sclarovsky S, Cannon C, McCabe C, Davis V, Zaret B, Wackers F, Braunwald E. Distortion of the Terminal Portion of the QRS on the Admission Electrocardiogram in Acute Myocardial Infarction and Correlation With Infarct Size and Long-Term Prognosis (Thrombolysis In Myocardial Infarction 4 Trial)**This study was supported in part by a grant from SmithKline Beecham, Philadelphia, Pennsylvania. The American Journal Of Cardiology 1996, 78: 396-403. PMID: 8752182, DOI: 10.1016/s0002-9149(96)00326-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAngina PectorisCardiac Output, LowCoronary AngiographyCreatine KinaseDouble-Blind MethodElectrocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionPatient AdmissionPrognosisRecurrenceRetrospective StudiesStroke VolumeSurvival RateTechnetium Tc 99m SestamibiThrombolytic TherapyTreatment OutcomeVentricular Function, LeftConceptsAcute myocardial infarctionLong-term prognosisAnterior acute myocardial infarctionCreatine kinase releaseInfarct sizeMyocardial infarctionMyocardial infarction (TIMI) 4 trialAnterior AMI patientsOne-year mortalityCoronary angiographic findingsLarger infarct sizeVentricular ejection fractionAdmission electrocardiogramHospital mortalityPrevious anginaSestamibi defectsAngiographic findingsBaseline characteristicsEjection fractionHeart failureAMI patientsClinical outcomesQRS distortionPatientsEnd pointPrognostic value of noninvasive testing one year after orthotopic cardiac transplantation
Verhoeven P, Lee F, Ramahi T, Franco K, de Leon C, Amatruda J, Gorham N, Mattera J, Wackers F. Prognostic value of noninvasive testing one year after orthotopic cardiac transplantation. Journal Of The American College Of Cardiology 1996, 28: 183-189. PMID: 8752812, DOI: 10.1016/0735-1097(96)00094-0.Peer-Reviewed Original ResearchConceptsCoronary artery vasculopathyOrthotopic cardiac transplantationCardiac transplantationEquilibrium radionuclide angiographyPrognostic valueRadionuclide angiographyClinical variablesNoninvasive testingHuman leukocyte antigen mismatchesStress thallium-201 imagingThallium-201 myocardial perfusion imagingConsecutive transplant recipientsRoutine noninvasive testingStress myocardial imagingCold ischemic timeStress myocardial perfusionThallium-201 imagingTwo-dimensional echocardiographyNoninvasive diagnostic testingMyocardial perfusion imagingOnly significant predictorAntigen mismatchesLate deathsTransplant recipientsIschemic timeDetection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina
Moriel M, Benhorin J, Brown M, Raubertas R, Severski P, Van Voorhees L, Bodenheimer M, Tzivoni D, Wackers F, Moss A, Group T. Detection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina. The American Journal Of Cardiology 1996, 77: 798-804. PMID: 8623730, DOI: 10.1016/s0002-9149(97)89172-2.Peer-Reviewed Original ResearchConceptsAcute coronary eventsThallium-201 stress scintigraphyPrimary end pointCoronary eventsEnd pointUnstable anginaStress scintigraphyPatient 1Myocardial infarctionNoninvasive testsExercise electrocardiogramAmbulatory electrocardiogramIschemia detectionCardiac event rateNonfatal myocardial infarctionSubsequent cardiac eventsAcute myocardial infarctionCardiac eventsIschemia testCardiac deathCox analysisPrognostic significanceMyocardial ischemiaEvent ratesWomen
1995
Preoperative Dipyridamole Thallium Imaging and Ambulatory Electrocardiographic Monitoring as a Predictor of Perioperative Cardiac Events and Long-term Outcome
Fleisher L, Rosenbaum S, Nelson A, Jain D, Wackers F, Zaret B. Preoperative Dipyridamole Thallium Imaging and Ambulatory Electrocardiographic Monitoring as a Predictor of Perioperative Cardiac Events and Long-term Outcome. Anesthesiology 1995, 83: 906-917.. PMID: 7486176, DOI: 10.1097/00000542-199511000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDipyridamoleElectrocardiography, AmbulatoryFemaleHeart DiseasesHumansIntraoperative ComplicationsMaleMiddle AgedPostoperative ComplicationsPredictive Value of TestsPreoperative CarePrognosisProspective StudiesRadionuclide AngiographySensitivity and SpecificitySurvival AnalysisThallium RadioisotopesVasodilator AgentsConceptsPerioperative cardiac eventsPredictive valueDipyridamole thalliumCardiac eventsPreoperative dipyridamole thallium imagingLong-term cardiac survivalGreatest likelihood ratioNoncardiac surgery patientsPerioperative cardiac morbidityDipyridamole-thallium imagingLong-term mortalityLong-term prognosisAmbulatory electrocardiographic monitoringShort-term outcomesLong-term outcomesLikelihood ratioPositive predictive valueLog-rank statisticsNuclear cardiology laboratoryCardiac morbidityNoncardiac surgerySurgery patientsThallium imagingCardiac survivalElectrocardiographic monitoringValue of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: Results of thrombolysis in myocardial infarction (TIMI) phase II study
Zaret B, Wackers F, Terrin M, Forman S, Williams D, Knatterud G, Braunwald E, Group F. Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: Results of thrombolysis in myocardial infarction (TIMI) phase II study. Journal Of The American College Of Cardiology 1995, 26: 73-79. PMID: 7797778, DOI: 10.1016/0735-1097(95)00146-q.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionExercise left ventricular ejection fractionPeak exercise ejection fractionExercise ejection fractionEjection fractionAcute myocardial infarctionImportant prognostic indexThrombolytic therapyPrethrombolytic eraCardiac mortalityPrognostic indexPrognostic valueMyocardial infarctionMortality rateMyocardial Infarction Phase II (TIMI II) studyMyocardial Infarction trialRest ejection fractionSubmaximal supine exercisePhase II studySurvival of patientsResults of thrombolysisHigh mortality rateCause mortalityII study
1994
Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina
Bodenheimer M, Wackers F, Schwartz R, Brown M, Group T. Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina. The American Journal Of Cardiology 1994, 74: 1196-1200. PMID: 7977089, DOI: 10.1016/0002-9149(94)90547-9.Peer-Reviewed Original ResearchConceptsNonfatal infarctionCardiac eventsUnstable anginaCardiac deathMyocardial infarctionReversible defectsExercise thallium studiesNonfatal myocardial infarctionAcute coronary eventsLarge prospective studiesAcute cardiac eventsKaplan-Meier curvesAcute myocardial infarctionLog-rank statisticsCoronary eventsExercise thalliumPatient 1Prognostic significanceProspective studyMyocardial ischemiaThallium studiesThallium testThallium imagesInfarctionPatientsLimited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease
Krone R, Gregory J, Freedland K, Kleiger R, Wackers F, Bodenheimer M, Benhorin J, Schwartz R, Parker J, van Voorhees L, Moss A, Group F. Limited usefulness of exercise testing and thallium scintigraphy in evaluation of ambulator patients several months after recovery from an acute coronary event: Implications for management of stable coronary heart disease. Journal Of The American College Of Cardiology 1994, 24: 1274-1281. PMID: 7930250, DOI: 10.1016/0735-1097(94)90109-0.Peer-Reviewed Original ResearchConceptsStable coronary diseaseAcute coronary eventsNonfatal myocardial infarctionThallium-201 scintigraphyCardiac eventsCoronary eventsCoronary diseaseCardiac deathHospital admissionMyocardial infarctionNonfatal infarctionEnd pointUnstable anginaExercise testingObstructive coronary artery diseaseStable coronary heart diseaseExercise testing variablesSubsequent cardiac eventsCoronary artery diseaseGroup of patientsCoronary heart diseaseProportional hazards modelThallium perfusionCardiac causesIdentifies patientsOne-year prognosis of patients with normal planar or single-photon emission computed tomographic technetium 99m-labeled sestamibi exercise imaging
Raiker K, Sinusas A, Wackers F, Zaret B. One-year prognosis of patients with normal planar or single-photon emission computed tomographic technetium 99m-labeled sestamibi exercise imaging. Journal Of Nuclear Cardiology 1994, 1: 449-456. PMID: 9420729, DOI: 10.1007/bf02961599.Peer-Reviewed Original ResearchConceptsNondiagnostic exercise electrocardiogramsPositive exercise electrocardiogramExercise electrocardiogramPrognostic significanceSingle photon emissionHigher cardiac event rateCardiac event rateChest pain syndromeNegative exercise electrocardiogramNonfatal myocardial infarctionOne-year prognosisPositive stress electrocardiogramCoronary artery diseaseFavorable prognostic significanceMyocardial perfusion imagingStress perfusion imagesCardiac causesCardiac eventsPain syndromeArtery diseaseConsecutive patientsExercise SPECTMyocardial infarctionFavorable outcomeStress electrocardiogram
1993
Myocardial risk area defined by technetium-99m sestamibi imaging during percutaneous transluminal coronary angioplasty: Comparison with coronary angiography
Haronian H, Remetz M, Sinusas A, Baron J, Miller H, Cleman M, Zaret B, Wackers F. Myocardial risk area defined by technetium-99m sestamibi imaging during percutaneous transluminal coronary angioplasty: Comparison with coronary angiography. Journal Of The American College Of Cardiology 1993, 22: 1033-1043. PMID: 8409038, DOI: 10.1016/0735-1097(93)90413-u.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAngioplasty, Balloon, CoronaryClinical ProtocolsCollateral CirculationCoronary AngiographyCoronary DiseaseEvaluation Studies as TopicFemaleHumansMaleMiddle AgedMyocardial InfarctionObserver VariationPredictive Value of TestsPrognosisReproducibility of ResultsRisk FactorsSeverity of Illness IndexTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsMyocardial risk areaCoronary angiographyCoronary angioplastyQuantitative myocardial perfusionMyocardial perfusionMyocardial areaPercutaneous transluminal coronary angioplastyAngiographic risk scoresSmall risk areasTransluminal coronary angioplastyCoronary artery diseaseCoronary artery stenosisInitial myocardial uptakeAngioplasty balloon inflationArtery diseaseLeft anteriorNonperfused areaArtery stenosisCoronary anatomyCoronary arteryBalloon inflationPatient managementMyocardial uptakeRisk scoreAngioplastyNuclear Cardiology
Zaret B, Wackers F. Nuclear Cardiology. New England Journal Of Medicine 1993, 329: 855-863. PMID: 8355745, DOI: 10.1056/nejm199309163291208.Peer-Reviewed Original ResearchNuclear Cardiology
Zaret B, Wackers F. Nuclear Cardiology. New England Journal Of Medicine 1993, 329: 775-783. PMID: 8350888, DOI: 10.1056/nejm199309093291107.Peer-Reviewed Original Research
1992
Comparison of thallium-201 and technetium-99m methoxyisobutyl isonitrile
Wackers F. Comparison of thallium-201 and technetium-99m methoxyisobutyl isonitrile. The American Journal Of Cardiology 1992, 70: e30-e34. PMID: 1442570, DOI: 10.1016/0002-9149(92)90036-x.Peer-Reviewed Original ResearchConceptsThallium-201Coronary artery diseaseComparative clinical trialsSimilar diagnostic yieldSingle photon emissionSymptomatic patientsArtery diseaseMethoxyisobutyl isonitrileNormalcy ratePrognostic significanceViable myocardiumClinical trialsDiagnostic yieldNumerous patientsMyocardial perfusionDiagnostic concordanceImaging protocolClinical applicationPatientsPrognostic proceduresGood specificityTechnetiumAgentsPerfusionMyocardium
1990
Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction
ZARET B, WACKERS F. Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction. Annals Of The New York Academy Of Sciences 1990, 601: 107-118. PMID: 2221682, DOI: 10.1111/j.1749-6632.1990.tb37296.x.Peer-Reviewed Original ResearchMeSH KeywordsCoronary DiseaseElectrocardiographyHeartHumansMyocardial InfarctionPrognosisRadionuclide ImagingConceptsMyocardial perfusion scintigraphyPerfusion scintigraphyMyocardial ischemiaPresence of reperfusionChronic coronary syndromeChronic coronary diseaseChronic myocardial ischemiaSignificant Q wavesElectrocardiographic documentationCoronary syndromeCoronary diseaseElectrocardiographic changesThrombolytic therapyMyocardial infarctionLimitations of electrocardiographyPharmacologic stressPrognostic evaluationQ wavesInfarct zoneScintigraphyIschemiaInfarctionPatientsCumulative experienceReperfusion