1997
Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease
Khattar R, Hendel R, Crawley J, Wackers F, Rigo P, Zaret B, Sridhara B, Lahiri A. Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 291-297. PMID: 9278875, DOI: 10.1016/s1071-3581(97)90106-9.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseROC curve analysisPrevious myocardial infarctionArtery diseaseCurve analysisMyocardial infarctionMulticenter phase III trialTechnetium 99m-labeled tetrofosminDiagnostic accuracySingle-vessel diseasePhase III trialsCharacteristic curve analysisMultivessel diseaseIII trialsCoronary arteriographyROC curve areaThallium-201TetrofosminDiagnostic testsDiseaseDiagnostic performanceCurve areaInfarctionReference standardPlanar imaging
1996
Quantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects
Siebelink H, Natale D, Sinusas A, Wackers F. Quantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects. Journal Of Nuclear Cardiology 1996, 3: 483-493. PMID: 8989673, DOI: 10.1016/s1071-3581(96)90058-6.Peer-Reviewed Original ResearchConceptsDefect reversibilitySingle photon emissionDual-isotope SPECTNormal databaseStress-rest single-photon emissionTechnetium 99m-labeled sestamibiStress-induced myocardial ischemiaStress single-photon emissionPerfusion defect reversibilityPrior myocardial infarctionDefect sizeRest/stressSingle-isotope imagingMyocardial infarctionThallium SPECTMyocardial ischemiaIndividual patientsMyocardial perfusionThallium-201PatientsSestamibiCircumferential count profilesTomographic imagingImaging protocolDual-isotope imagingDiagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: Results of a phase III multicenter trial
Hendel R, Verani M, Miller D, Wackers F, McMahon M, Cerqueira M, Botvinick E, Kvols L, Gerson M. Diagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: Results of a phase III multicenter trial. Journal Of Nuclear Cardiology 1996, 3: 291-300. PMID: 8799247, DOI: 10.1016/s1071-3581(96)90088-4.Peer-Reviewed Original ResearchConceptsMyocardial perfusion agentPerfusion agentMulticenter trialNormalcy ratePhase III multicenter trialCoronary artery diseaseTomographic myocardial perfusionMyocardial perfusion imagingPanel of readersNew myocardial perfusion agentNew perfusion tracerPeak exerciseArtery diseaseThallium scintigraphyPerfusion scintigraphyMyocardial scintigraphyExercise workloadStudy groupLaboratory alterationsMyocardial perfusionThallium-201Perfusion imagingDiagnostic utilityScintigraphyPerfusion studies
1994
The maze of myocardial perfusion imaging protocols in 1994
Wackers F. The maze of myocardial perfusion imaging protocols in 1994. Journal Of Nuclear Cardiology 1994, 1: 180-188. PMID: 9420685, DOI: 10.1007/bf02984090.Peer-Reviewed Original Research
1992
Comparison of thallium-201 and technetium-99m methoxyisobutyl isonitrile
Wackers F. Comparison of thallium-201 and technetium-99m methoxyisobutyl isonitrile. The American Journal Of Cardiology 1992, 70: e30-e34. PMID: 1442570, DOI: 10.1016/0002-9149(92)90036-x.Peer-Reviewed Original ResearchConceptsThallium-201Coronary artery diseaseComparative clinical trialsSimilar diagnostic yieldSingle photon emissionSymptomatic patientsArtery diseaseMethoxyisobutyl isonitrileNormalcy ratePrognostic significanceViable myocardiumClinical trialsDiagnostic yieldNumerous patientsMyocardial perfusionDiagnostic concordanceImaging protocolClinical applicationPatientsPrognostic proceduresGood specificityTechnetiumAgentsPerfusionMyocardium
1991
Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest
Kayden D, Sigal S, Soufer R, Mattera J, Zaret B, Wackers F. Thallium-201 for assessment of myocardial viability: Quantitative comparison of 24-hour redistribution imaging with imaging after reinjection at rest. Journal Of The American College Of Cardiology 1991, 18: 1480-1486. PMID: 1939949, DOI: 10.1016/0735-1097(91)90678-3.Peer-Reviewed Original ResearchConceptsInjection of thalliumRedistribution imagesDefect reversibilityThallium-201 reinjectionThallium-201 defectsLate redistribution imagingPoor quality studiesDiagnostic informationClinical variablesRedistribution imagingThallium defectsThallium imagesMyocardial viabilityReversible defectsStress imagingThallium-201PatientsBetter diagnostic informationStress testingExercisePresent studyQuality studiesInjectionLate redistributionReinjection
1989
Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy
Wackers F, Gibbons R, Verani M, Kayden D, Pellikka P, Behrenbeck T, Mahmarian J, Zaret B. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy. Journal Of The American College Of Cardiology 1989, 14: 861-873. PMID: 2507612, DOI: 10.1016/0735-1097(89)90456-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorAcute myocardial infarctionPatent infarct-related arteryInfarct-related arteryThallium-201 imagingThrombolytic therapyMyocardial infarctionPlanar technetiumMyocardial perfusionExercise thallium-201 imagingFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionSuccess of reperfusionMyocardial blood flowNew myocardial perfusionTissue-type plasminogen activatorArtery patencyChest painCoronary occlusionRepeat imagingBlood flowInfarctionThallium-201Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging.
Wackers F, Berman D, Maddahi J, Watson D, Beller G, Strauss H, Boucher C, Picard M, Holman B, Fridrich R. Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. Journal Of Nuclear Medicine 1989, 30: 301-11. PMID: 2525610.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseaseMulticenter phase II clinical trialSignificant coronary artery diseasePhase II clinical trialMulticenter phase IStress imagesMyocardial perfusion imagingNew myocardial imaging agentHuman biodistributionClinical efficacyClinical trialsMyocardial analysisStress imagingMyocardial imaging agentMyocardial uptakeMyocardial segmentsNormal volunteersThallium-201Myocardial imagingPerfusion imagingPatientsPhase IExact concordanceMyocardial images
1980
Myocardial Imaging with Thallium-201 and Technetium-99m-Pyrophosphate in the Coronary Care Unit: Conclusion
Wackers F, Willerson J. Myocardial Imaging with Thallium-201 and Technetium-99m-Pyrophosphate in the Coronary Care Unit: Conclusion. Developments In Cardiovascular Medicine 1980, 9: 241-244. DOI: 10.1007/978-94-009-8904-7_14.Peer-Reviewed Original ResearchAcute myocardial infarctionMyocardial infarctionMyocar-dial infarctionAcute chest painCoronary care unitChest painCare unitClinical recognitionTechnetium-99mPatient historyThallium-201Myocardial imagingSerum enzymesInfarctionPatientsImaging techniquesSuccessful visualizationFirst reportMultiple reasonsPainMyocardiumDiagnosis
1978
Prevalence of right ventricular involvement in inferior wall infarction assessed with myocardial imaging with thallium-201 and technetium-99m pyrophosphate
Wackers F, Lie K, Sokole E, Res J, Van Der Schoot J, Durrer D. Prevalence of right ventricular involvement in inferior wall infarction assessed with myocardial imaging with thallium-201 and technetium-99m pyrophosphate. The American Journal Of Cardiology 1978, 42: 358-362. PMID: 210648, DOI: 10.1016/0002-9149(78)90928-1.Peer-Reviewed Original ResearchConceptsRight ventricular involvementAcute inferior wall infarctionInferior wall infarctionVentricular involvementThallium-201Myocardial imagingSevere right ventricular failurePump failurePositive pyrophosphate scansSevere pump failureRight ventricular failureSubgroup of patientsThallium-201 defectsPyrophosphate scanCardiogenic shockVentricular dysfunctionVentricular failureConsecutive patientsConsecutive seriesClassic signsPatientsClinical relevanceInfarctionNonivasive methodVolume loading
1977
Location and size of acute transmural myocardial infarction estimated from thallium-201 scintiscans. A clinicopathological study.
Wackers F, Becker A, Samson G, Sokole E, van der Schoot J, Vet A, Lie K, Durrer D, Wellens H. Location and size of acute transmural myocardial infarction estimated from thallium-201 scintiscans. A clinicopathological study. Circulation 1977, 56: 72-78. PMID: 862174, DOI: 10.1161/01.cir.56.1.72.Peer-Reviewed Original ResearchConceptsAcute transmural myocardial infarctionSize of infarctionTransmural myocardial infarctionClinicopathological studyMyocardial infarctionPostmortem findingsThallium-201 scintigraphyScintigraphic locationAcute phaseNecrotic myocardiumInfarctionThallium-201Abnormal areasScintiscanScintigraphyPatientsECGDays
1975
Noninvasive visualization of acute myocardial infarction in man with thallium-201.
Wackers F, Schoot J, Sokole E, Samson G, Niftrik G, Lie K, Durrer D, Wellens H. Noninvasive visualization of acute myocardial infarction in man with thallium-201. Heart 1975, 37: 741. PMID: 1156481, PMCID: PMC482866, DOI: 10.1136/hrt.37.7.741.Peer-Reviewed Original Research