2019
Renal Effects of Intensive Volume Removal in Heart Failure Patients With Preexisting Worsening Renal Function
Rao VS, Ahmad T, Brisco-Bacik MA, Bonventre JV, Wilson FP, Siew ED, Felker GM, Anstrom KK, Mahoney DD, Bart BA, Tang WHW, Velazquez EJ, Testani JM. Renal Effects of Intensive Volume Removal in Heart Failure Patients With Preexisting Worsening Renal Function. Circulation Heart Failure 2019, 12: e005552. PMID: 31163974, PMCID: PMC6585463, DOI: 10.1161/circheartfailure.118.005552.Peer-Reviewed Original ResearchConceptsRenal tubular injury biomarkersTubular injury biomarkersHeart failure patientsAcute decompensated heart failure patientsDecompensated heart failure patientsTubular injury markersInjury biomarkersFailure patientsRenal functionInjury markersAcute decompensated heart failureVolume removalCARRESS-HF trialRenal function recoveryDecompensated heart failureRenal tubular injuryRenal effectsSerum creatinineTubular injuryBiomarker substudyHeart failurePharmacological therapyClinical outcomesFunction recoveryHigh incidence
2018
The Renal Effects of Aggressive Volume Removal in Heart Failure Patients with Preexisting Worsening Renal Function
Mahoney D, Ahmad T, Rao V, Brisco-Bacik M, Wilson F, Siew E, Felker G, Anstrom K, Bart B, Tang W, O'Connor C, Velazquez E, Testani J. The Renal Effects of Aggressive Volume Removal in Heart Failure Patients with Preexisting Worsening Renal Function. Journal Of Cardiac Failure 2018, 24: s26. DOI: 10.1016/j.cardfail.2018.07.074.Peer-Reviewed Original ResearchRenal tubular injury biomarkersTubular injury biomarkersRenal tubular injuryHeart failure patientsInjury biomarkersTubular injuryFailure patientsRenal functionAcute decompensated heart failure patientsDecompensated heart failure patientsVolume removalCARRESS-HF trialRenal function recoveryTubular injury markersWorsening Renal FunctionHalf of patientsADHF patientsEffective decongestionRenal effectsInjury markersPharmacologic therapyTransient findingFunction recoveryHigh incidencePatientsWorsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM. Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury. Circulation 2018, 137: 2016-2028. PMID: 29352071, PMCID: PMC6066176, DOI: 10.1161/circulationaha.117.030112.Peer-Reviewed Original ResearchMeSH KeywordsAcetylglucosaminidaseAcute DiseaseAcute Kidney InjuryAgedAged, 80 and overBiomarkersCreatinineCystatin CDiuresisFemaleGlomerular Filtration RateHeart FailureHepatitis A Virus Cellular Receptor 1HumansKidneyLipocalin-2MaleMiddle AgedSodium Potassium Chloride Symporter InhibitorsTime FactorsTreatment OutcomeUnited StatesConceptsKidney injury molecule-1Neutrophil gelatinase-associated lipocalinInjury molecule-1Acute heart failureGelatinase-associated lipocalinRenal tubular injuryTubular injury biomarkersAggressive diuresisROSE-AHF trialsTubular injuryInjury biomarkersRenal functionHeart failureMolecule-1D-glucosaminidaseHigh-dose loop diuretic therapyAcute heart failure treatmentKidney tubular injuryLoop diuretic therapyAcute kidney injuryGlomerular filtration rateHeart failure treatmentDiuretic therapyFurosemide equivalentsKidney injury
2017
Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury
Moledina DG, Hall IE, Thiessen-Philbrook H, Reese PP, Weng FL, Schröppel B, Doshi MD, Wilson FP, Coca SG, Parikh CR. Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury. American Journal Of Kidney Diseases 2017, 70: 807-816. PMID: 28844586, PMCID: PMC5701867, DOI: 10.1053/j.ajkd.2017.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultArea Under CurveBiomarkersCohort StudiesCreatinineCross-Sectional StudiesFatty Acid-Binding ProteinsFemaleHepatitis A Virus Cellular Receptor 1HumansInterleukin-18Kidney TransplantationKidney TubulesLipocalin-2MaleMiddle AgedProspective StudiesROC CurveSeverity of Illness IndexTissue DonorsConceptsSevere acute tubular injuryAcute kidney injuryAcute tubular injuryTubular injurySCr concentrationNGAL concentrationsUrinary biomarkersDeceased donorsOrgan procurementMulticenter prospective cohortUrinary L-FABPUrinary NGAL concentrationsDeceased kidney donorsKidney injury biomarkersSerum creatinine concentrationPoor diagnostic performanceAKI casesAKI causesDonor hospitalizationKidney injuryProspective cohortSerum creatinineInjury biomarkersKidney biopsyIL-18
2016
Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression
Hsu CY, Xie D, Waikar SS, Bonventre JV, Zhang X, Sabbisetti V, Mifflin TE, Coresh J, Diamantidis CJ, He J, Lora CM, Miller ER, Nelson RG, Ojo AO, Rahman M, Schelling JR, Wilson FP, Kimmel PL, Feldman HI, Vasan RS, Liu KD, Investigators C, Appel L, Feldman H, Go A, He J, Kusek J, Lash J, Ojo A, Rahman M, Townsend R, Consortium C. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression. Kidney International 2016, 91: 196-203. PMID: 28029431, PMCID: PMC5362331, DOI: 10.1016/j.kint.2016.09.003.Peer-Reviewed Original ResearchMeSH KeywordsAcetylglucosaminidaseAgedAlbuminuriaBiomarkersCreatinineDisease ProgressionFatty Acid-Binding ProteinsFemaleFollow-Up StudiesGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansKidney Failure, ChronicKidney TubulesLipocalin-2MaleMiddle AgedProportional Hazards ModelsProspective StudiesRenal Insufficiency, ChronicRisk AssessmentRisk FactorsConceptsGlomerular filtration rateUrinary albumin/creatinine ratioAlbumin/creatinine ratioKidney disease progressionTubular injury biomarkersCKD progressionInjury biomarkersFiltration rateClinical modelSerum creatinineCreatinine ratioDisease progressionProspective Chronic Renal Insufficiency Cohort StudyChronic Renal Insufficiency Cohort (CRIC) StudyIncident end-stage renal diseaseUnadjusted Cox proportional hazards modelUrinary kidney injury molecule-1Renal tubular injury biomarkersChronic kidney disease progressionKidney injury molecule-1End-stage renal diseaseNeutrophil gelatinase-associated lipocalinCox proportional hazards modelBase clinical modelInjury molecule-1