2012
MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions
Chandhanayingyong C, Kim Y, Staples JR, Hahn C, Lee FY. MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions. Sarcoma 2012, 2012: 404810. PMID: 22577336, PMCID: PMC3345255, DOI: 10.1155/2012/404810.Peer-Reviewed Original ResearchBone sarcomasClinical trialsEwing's sarcomaLimb salvage surgeryCurrent therapeutic modalitiesRecent clinical trialsMAPK/ERK inhibitorsPromising therapeutic targetHigh-grade chondrosarcomaCytotoxic chemotherapeutic drugsMAPK/ERK signalingSalvage surgeryTherapy regimensClinical benefitMetastatic osteosarcomaInflammatory responseMAPK/ERKClinical dataLocal invasivenessTherapeutic modalitiesCurrent chemotherapyTherapeutic conceptsTherapeutic implicationsTherapeutic targetSarcoma
2007
Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells
Kim DW, Seo SW, Cho SK, Chang SS, Lee HW, Lee E, Block JA, Hei TK, Lee FY. Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. Journal Of Orthopaedic Research® 2007, 25: 820-828. PMID: 17343283, DOI: 10.1002/jor.20377.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisApoptosis Regulatory ProteinsBcl-X ProteinBone NeoplasmsCell Line, TumorCell SurvivalChondrocytesChondrosarcomaGene Expression Regulation, NeoplasticHumansProto-Oncogene Proteins c-bcl-2Radiation ToleranceRNA, MessengerRNA, Small InterferingX-Linked Inhibitor of Apoptosis ProteinConceptsBcl-xLCell deathChondrosarcoma cellsGene silencingBcl-2Cell survival genesHuman chondrosarcoma cell lineClonogenic survival assaysChondrosarcoma cell linesNovel therapeutic conceptsCorresponding siRNAAntiapoptotic genesApoptotic pathwaySurvival genesAntiapoptotic mRNAsCell survivalXIAP geneMost chondrosarcomasAdjuvant therapySurgical resectionGenesSurvival assaysTherapeutic conceptsCell linesSilencing