2012
Modern Interpretation of Giant Cell Tumor of Bone: Predominantly Osteoclastogenic Stromal Tumor
Kim Y, Nizami S, Goto H, Lee FY. Modern Interpretation of Giant Cell Tumor of Bone: Predominantly Osteoclastogenic Stromal Tumor. Clinics In Orthopedic Surgery 2012, 4: 107-116. PMID: 22662295, PMCID: PMC3360182, DOI: 10.4055/cios.2012.4.2.107.Peer-Reviewed Original ResearchConceptsGiant cell tumorStromal cell-derived factor-1Tumor necrosis factorCell tumorsBone destructionNuclear factor kappa-B ligandCell-derived factor-1Stromal cell tumorsPro-osteoclastogenic cytokinesGCT treatmentAdjuvant therapySurgical excisionStromal tumorsTumor comprisingInflammatory cytokinesChemoattractant proteinNecrosis factorParacrine loopExcessive osteoclastogenesisReceptor activatorOrthopaedic surgeonsOsteoclast precursorsOsteoclastic cellsMesenchymal originTumors
2009
Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis
Seo SW, Lee D, Minematsu H, Kim AD, Shin M, Cho SK, Kim DW, Yang J, Lee FY. Targeting extracellular signal-regulated kinase (ERK) signaling has therapeutic implications for inflammatory osteolysis. Bone 2009, 46: 695-702. PMID: 19895919, PMCID: PMC2823832, DOI: 10.1016/j.bone.2009.10.032.Peer-Reviewed Original ResearchConceptsInflammatory osteolysisInflammatory responseInnate immune responseExtracellular signal-regulated kinase (ERK) signalingImportant therapeutic targetM-CSF expressionSignal-regulated kinase 1/2 pathwaySignal-regulated kinase signalingExtracellular signal-regulated kinase 1/2 (ERK1/2) pathwayInhibition of ERKImmune responseTherapeutic implicationsTherapeutic targetOsteoclast precursorsKinase 1/2 pathwayM-CSFOsteolysisERK pathwayMacrophage colonyLPSERKERK signalsMitogen-activated protein kinase (MAPK) familyKinase signalingCell differentiation
2005
Recruitment of osteoclast precursors by stromal cell derived factor‐1 (SDF‐1) in giant cell tumor of bone
Liao TS, Yurgelun MB, Chang S, Zhang H, Murakami K, Blaine TA, Parisian M, Kim W, Winchester RJ, Lee F. Recruitment of osteoclast precursors by stromal cell derived factor‐1 (SDF‐1) in giant cell tumor of bone. Journal Of Orthopaedic Research® 2005, 23: 203-209. PMID: 15607894, DOI: 10.1016/j.orthres.2004.06.018.Peer-Reviewed Original ResearchConceptsGiant cell tumorSDF-1Osteoclast precursorsStromal cellsCell tumorsSDF-1 gene expressionTumor-induced osteoclastogenesisSDF-1 proteinRecombinant SDF-1Neoplastic stromal cellsReal-time RT-PCRHematopoetic stem cellsOsteoclast precursor cellsTime RT-PCRBone lesionsStudy of osteoclastogenesisChemotactic concentrationsChemoattractant factorGCT tissuesMonocyte/Specific receptorsRT-PCRDisease modelsPrecursor cellsFactor 1