Featured Publications
Construction and evaluation of a clinically relevant model of septic arthritis
Kwon H, Yu K, Lee F. Construction and evaluation of a clinically relevant model of septic arthritis. Lab Animal 2022, 52: 11-26. PMID: 36564668, DOI: 10.1038/s41684-022-01089-7.Peer-Reviewed Original ResearchConceptsSeptic arthritisAnimal modelsMethicillin-resistant Staphylococcus aureus culturesIntra-articular inflammationReproducible animal modelRelevant mouse modelExperimental animal modelsMRSA infectionCartilage destructionC57BL/6J miceInflammatory pathologyJoint diseaseTherapeutic medicationsMouse modelArthritisSynovial fluidClinical relevancePotential treatmentHuman patientsKnee jointDirect inoculationAureus culturesMRSAMiceStaphylococcus aureus cultures
2020
Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies
Yu K, Song L, Kang HP, Kwon HK, Back J, Lee FY. Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies. Bone And Joint Research 2020, 9: 49-59. PMID: 32435455, PMCID: PMC7229311, DOI: 10.1302/2046-3758.92.bjr-2019-0131.r1.Peer-Reviewed Original ResearchMethicillin-resistant Staphylococcus aureus (MRSA) infectionsEarly antibiotic administrationHours of injuryStandard of careStaphylococcus aureus infectionBone resident cellsEffect of cefazolinBone Joint ResAntibiotic regimensAntibiotic administrationCombined administrationAntibiotic treatmentAureus infectionProtective effectSurgical preparationMRSA growthOpen fracturesPreparation agentsDetergent susceptibilityPrimary murine osteoblastsBacterial bioburdenMRSAColony formationRifampicinBone cells