2017
BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing
Zhao W, Steinfeld JB, Liang F, Chen X, Maranon DG, Jian Ma C, Kwon Y, Rao T, Wang W, Sheng C, Song X, Deng Y, Jimenez-Sainz J, Lu L, Jensen RB, Xiong Y, Kupfer GM, Wiese C, Greene EC, Sung P. BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing. Nature 2017, 550: 360-365. PMID: 28976962, PMCID: PMC5800781, DOI: 10.1038/nature24060.Peer-Reviewed Original ResearchAmino Acid SequenceBase PairingBRCA1 ProteinBRCA2 ProteinChromosome PairingFanconi Anemia Complementation Group N ProteinGenes, BRCA1Genes, BRCA2HumansMultiprotein ComplexesMutationProtein BindingRad51 RecombinaseRecombinational DNA RepairSequence Homology, Nucleic AcidTemplates, GeneticTumor Suppressor ProteinsUbiquitin-Protein Ligases
2016
Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex
Liang F, Longerich S, Miller AS, Tang C, Buzovetsky O, Xiong Y, Maranon DG, Wiese C, Kupfer GM, Sung P. Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex. Cell Reports 2016, 15: 2118-2126. PMID: 27239033, PMCID: PMC5381662, DOI: 10.1016/j.celrep.2016.05.007.Peer-Reviewed Original ResearchConceptsHomologous recombinationFanconi anemia DNA damage response pathwayDNA damage response pathwaySmall ubiquitin-like modifierDNA damage hypersensitivityHomologous DNA pairingSUMO-interacting motifDamage response pathwayUbiquitin-like modifierFANCD2 ubiquitinationGenome maintenanceComplex formationNucleoprotein intermediatesRAD51 recombinaseDNA pairingProtein complexesBinds DNAAccessory factorsResponse pathwaysHomologous DNADNA repairLike domainUAF1RAD51RAD51AP1