2021
Right predominant electrical remodeling in a pure model of pulmonary hypertension promotes reentrant arrhythmias
Strauss B, Bisserier M, Obus E, Katz MG, Fargnoli A, Cacheux M, Akar JG, Hummel JP, Hadri L, Sassi Y, Akar FG. Right predominant electrical remodeling in a pure model of pulmonary hypertension promotes reentrant arrhythmias. Heart Rhythm 2021, 19: 113-124. PMID: 34563688, PMCID: PMC8742785, DOI: 10.1016/j.hrthm.2021.09.021.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionVT/VFExtrapulmonary toxicityPN ratsVentricular tachycardia/fibrillationCardiac magnetic resonance imagingRight ventricular hypertrophySprague-Dawley ratsMultiple reentrant circuitsConnexin 43 expressionMagnetic resonance imagingConnexin 43 phosphorylationRV activationArterial hypertensionMonocrotaline modelVentricular hypertrophyLeft pneumonectomyElectrical remodelingMyocardial fibrosisConduction slowingSevere formAP durationArrhythmic vulnerabilityReentrant circuitAP alternans
2005
Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts
Spragg DD, Akar FG, Helm RH, Tunin RS, Tomaselli GF, Kass DA. Abnormal conduction and repolarization in late-activated myocardium of dyssynchronously contracting hearts. Cardiovascular Research 2005, 67: 77-86. PMID: 15885674, DOI: 10.1016/j.cardiores.2005.03.008.Peer-Reviewed Original ResearchConceptsAction potential durationConduction velocityRefractory periodElectrophysiological remodelingArrhythmia susceptibilityIntraventricular conduction delayLeft ventricular dyssynchronyGap junction protein expressionJunction protein expressionCalcium cycling proteinsTotal expressionDyssynchronous heartsLV dysfunctionMechanical dyssynchronyUntreated dogsVentricular dyssynchronyCardiac dyssynchronyControl dogsLateral LVRadiofrequency ablationAnterior wallConduction delayDyssynchronyMyocardial segmentsPotential duration