2024
Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction
Rudokas M, McKay M, Toksoy Z, Eisen J, Bögner M, Young L, Akar F. Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction. Cardiovascular Diabetology 2024, 23: 261. PMID: 39026280, PMCID: PMC11264840, DOI: 10.1186/s12933-024-02357-1.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesMitochondrial network remodelingDamaged mitochondrial DNAEfficiency of oxidative phosphorylationImpaired ATP productionMitochondrial ultrastructural alterationsCardiac functionDiabetic heartCellular energy metabolismProduction of reactive oxygen speciesMitochondrial DNAMitochondrial networkMitochondrial fissionExcessive production of reactive oxygen speciesOxidative phosphorylationATP productionResponse to ischemic insultGlobal cardiac functionCell deathOverall cardiac functionCardiac ischemic injuryResponse to injuryCardiac mitochondriaIrreversible cell deathMitochondria
2022
Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function
Rudokas M, Cacheux M, Akar F. Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function. 2022, 197-211. DOI: 10.1007/978-3-031-08309-9_6.BooksMitochondrial dynamicsNormal embryonic developmentMitochondrial dynamics proteinsDynamic organellesMitochondrial networkMitochondrial fusionDynamic proteinsEmbryonic developmentFragmented mitochondriaKey proteinsKey regulatorFunctional importanceMetabolic regulationAltered regulationMitochondriaFission eventsFundamental processesProteinCardiac mitochondriaFission resultsRegulationMorphological changesRecent advancesOrganellesRegulator
2011
Mitochondria are sources of metabolic sink and arrhythmias
Akar FG, O'Rourke B. Mitochondria are sources of metabolic sink and arrhythmias. Pharmacology & Therapeutics 2011, 131: 287-294. PMID: 21513732, PMCID: PMC3138548, DOI: 10.1016/j.pharmthera.2011.04.005.Peer-Reviewed Original Research