Modulation of Neuronal Excitability by Serotonin-NMDA Interactions in Prefrontal Cortex
Zhong P, Yuen E, Yan Z. Modulation of Neuronal Excitability by Serotonin-NMDA Interactions in Prefrontal Cortex. Molecular And Cellular Neuroscience 2008, 38: 290-299. PMID: 18455431, PMCID: PMC2477738, DOI: 10.1016/j.mcn.2008.03.003.Peer-Reviewed Original ResearchMeSH Keywords8-Hydroxy-2-(di-n-propylamino)tetralinAction PotentialsAnimalsExcitatory Amino Acid AgonistsExtracellular Signal-Regulated MAP KinasesMAP Kinase Signaling SystemN-MethylaspartateOrgan Culture TechniquesPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptors, N-Methyl-D-AspartateSerotoninSerotonin Receptor AgonistsStress, PhysiologicalSwimmingConceptsExtracellular signal-regulated kinaseProtein kinase AProtein kinase CActivation of ERKSignal-regulated kinaseNeuronal excitabilityKinase AMolecule downstreamERK activationPrefrontal cortexKinase CNMDA receptorsStressful conditionsMental disordersBiochemical evidencePFC neuronal firingPFC pyramidal neuronsPresence of NMDAAction potential firingNMDA-dependent mannerDPAT effectsAgonist alphaPyramidal neuronsReceptor subtypesActivation