2012
Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease
Yuen EY, Wei J, Zhong P, Yan Z. Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington's disease. Neurobiology Of Disease 2012, 46: 497-502. PMID: 22402331, PMCID: PMC3323696, DOI: 10.1016/j.nbd.2012.02.015.Peer-Reviewed Original ResearchConceptsHuntingtin associated protein 1Mouse modelHuntington's diseaseSynaptic inhibitionExcitatory/inhibitory balanceInhibitory synaptic efficacyDiminished surface expressionNeurodegenerative movement disorderTransgenic mouse modelHD mouse modelsNeuronal excitotoxicityInhibitory balanceMovement disordersAssociated protein 1Synaptic transmissionGABAAR traffickingSynaptic efficacySynaptic functionDiseaseReceptorsMutant huntingtinProtein 1Protein 5Surface expressionPolyglutamine repeats
2011
Impaired α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking and Function by Mutant Huntingtin*
Mandal M, Wei J, Zhong P, Cheng J, Duffney L, Liu W, Yuen E, Twelvetrees A, Li S, Li X, Kittler J, Yan Z. Impaired α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Trafficking and Function by Mutant Huntingtin*. Journal Of Biological Chemistry 2011, 286: 33719-33728. PMID: 21832090, PMCID: PMC3190808, DOI: 10.1074/jbc.m111.236521.Peer-Reviewed Original ResearchConceptsMiniature excitatory postsynaptic currentsMouse modelMutant huntingtinAMPAR-mediated synaptic transmissionHuntington Disease PathophysiologyAMPAR-mediated miniature excitatory postsynaptic currentsExcitatory postsynaptic currentsTransgenic mouse modelHD mouse modelsIsoxazolepropionic acid receptor (AMPAR) traffickingReceptor traffickingAMPA receptor traffickingPolyQ-httGlutamatergic transmissionPostsynaptic currentsSynaptic excitationSynaptic transmissionAMPA receptorsWild-type huntingtinNeuronal culturesDisease pathophysiologySynaptic functionAMPAR traffickingΑ-aminoDiminished strength