2008
Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex*
Yuen EY, Jiang Q, Chen P, Feng J, Yan Z. Activation of 5-HT2A/C Receptors Counteracts 5-HT1A Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex*. Journal Of Biological Chemistry 2008, 283: 17194-17204. PMID: 18442977, PMCID: PMC2427346, DOI: 10.1074/jbc.m801713200.Peer-Reviewed Original ResearchConceptsPFC pyramidal neuronsExtracellular signal-regulated kinasePyramidal neuronsPrefrontal cortexNMDAR currentsN-methyl-D-aspartate receptor currentsN-methyl-D-aspartate receptor channelsSynaptic NMDAR responsesNMDAR responsesNMDAR functionActivation of ERKDendritic processesReceptor currentsPFC neuronsSignal-regulated kinaseReceptor activationMental disordersImmunocytochemical studyIntact animalsCounteractive effectsReceptor channelsInhibitory effectNeuronsCellular knockdownDependent pathway
2005
Microtubule Regulation of N-Methyl-D-aspartate Receptor Channels in Neurons*
Yuen EY, Jiang Q, Feng J, Yan Z. Microtubule Regulation of N-Methyl-D-aspartate Receptor Channels in Neurons*. Journal Of Biological Chemistry 2005, 280: 29420-29427. PMID: 15975919, DOI: 10.1074/jbc.m504499200.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptorsMicrotubule depolymerizerNMDAR currentsNMDA receptorsRole of microtubulesMicrotubule regulationActin cytoskeletonBrain-derived neurotrophic factorCellular knockdownNMDAR traffickingMicrotubule-depolymerizing agentCortical pyramidal neuronsN-methyl-D-aspartate receptor channelsDendritic transportHigh NMDA concentrationsMicrotubulesPyramidal neuronsNeurotrophic factorNMDAR functionNMDA concentrationSynaptic currentsNeuronal dendritesSynaptic plasticityMicrotubule stabilizerImmunocytochemical study