2017
Molecular and Epigenetic Mechanisms for the Complex Effects of Stress on Synaptic Physiology and Cognitive Functions
Yuen EY, Wei J, Yan Z. Molecular and Epigenetic Mechanisms for the Complex Effects of Stress on Synaptic Physiology and Cognitive Functions. The International Journal Of Neuropsychopharmacology 2017, 20: 948-955. PMID: 29016816, PMCID: PMC5737802, DOI: 10.1093/ijnp/pyx052.Peer-Reviewed Original ResearchConceptsEpigenetic mechanismsReceptor membrane traffickingStress-induced regulationSynaptic physiologyMembrane traffickingEpigenetic controlCytoskeleton networkGene expressionKey moleculesComplex effectsStress-related mental disordersPresynaptic glutamate releaseExcitatory synaptic transmissionStress-induced modulationPhysiologyGlutamatergic transmissionGlutamate releaseSynaptic transmissionBiphasic effectAnimal studiesComplex changesMental disordersBrain regionsChronic stressStress hormones
2010
Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors
Yuen EY, Zhong P, Yan Z. Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 22308-22313. PMID: 21135234, PMCID: PMC3009820, DOI: 10.1073/pnas.1010025108.Peer-Reviewed Original ResearchConceptsSynaptic transmissionPrefrontal cortex pyramidal neuronsCortex pyramidal neuronsExcitatory synaptic transmissionAttention deficit hyperactivity disorderRole of dopamineDopamine D4 receptorGlutamatergic transmissionPyramidal neuronsCortical excitabilityProfound depressionMental disordersSynaptic functionBrain regionsD4 receptorsSynaptic factorsAMPAR traffickingPrefrontal cortexDistinct signaling pathwaysHyperactivity disorderCaMKII activityBidirectional regulationHomeostatic regulationReceptorsSignaling pathways
2009
Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory
Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z. Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 14075-14079. PMID: 19666502, PMCID: PMC2729022, DOI: 10.1073/pnas.0906791106.Peer-Reviewed Original ResearchConceptsAcute stressPrefrontal cortexGlucocorticoid receptorPotentiation of NMDARPFC pyramidal neuronsLong-term potentiationKey brain regionsCorticosteroid stress hormonesGR-dependent mechanismGlutamatergic transmissionPyramidal neuronsSynaptic transmissionBehavioral stressorsSynaptic currentsPFC neuronsBehavioral testsBrain regionsChronic stressAMPAR subunitsRecurrent excitationStress hormonesBeneficial effectsCellular mechanismsSurface expressionNMDAR
2007
Serotonergic Regulation of NMDA Receptor Trafficking and Function in Prefrontal Cortex
Yuen E, Yan Z. Serotonergic Regulation of NMDA Receptor Trafficking and Function in Prefrontal Cortex. 2007, 91-101. DOI: 10.1007/978-0-387-72256-6_5.Peer-Reviewed Original ResearchPrefrontal cortexPFC neuronsBrain stem raphe nucleiPrimary neuronal populationsPyramidal projection neuronsNMDA receptor traffickingMultiple brain regionsProjection neuronsRaphe nucleusBasal gangliaBrain stemGABAergic interneuronsLimbic areasSerotonergic regulationWidespread projectionsNeuronal populationsFrontal lobeBehavioral testsBrain regionsDelayed-response taskCortexNeuronsMajor targetReceptor traffickingSerotonin