2017
Mining the Human Gut Microbiota for Immunomodulatory Organisms
Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan T, Ortiz-Lopez A, Yanortsang T, Yang L, Jupp R, Mathis D, Benoist C, Kasper D. Mining the Human Gut Microbiota for Immunomodulatory Organisms. Cell 2017, 168: 928-943.e11. PMID: 28215708, PMCID: PMC7774263, DOI: 10.1016/j.cell.2017.01.022.Peer-Reviewed Original ResearchConceptsGut microbiotaHuman gut microbesHuman gut microbiotaIndividual bacterial speciesGut microbesMicrobial phylogenyHuman gutDiverse microbesEpigenetic systemsMicrobial diversityBacterial speciesMicrobiota's abilityMicrobesMicrobiotaMonocolonized miceGutImmunological adaptationsHostImmune systemPhylogenyImmune parametersPhylogeneticallyImmunomodulatory effectsSpeciesDiversity
2011
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice
Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 11548-11553. PMID: 21709219, PMCID: PMC3136249, DOI: 10.1073/pnas.1108924108.Peer-Reviewed Original ResearchConceptsDiabetes protectionSFB colonizationSmall intestinal lamina propriaSystemic lymphoid tissuesExperimental autoimmune encephalomyelitisNonobese diabetic (NOD) miceT cell compartmentImmune system alterationsType 1 diabetesDifferent Th subsetsSegmented filamentous bacteriaHost physiological functionsNOD miceAutoimmune encephalomyelitisInflammatory arthritisTh17 cellsTh subsetsAutoimmune responseDiabetic miceLymphoid tissueSI-LPSpontaneous modelT cellsLamina propriaMouse model