Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial
Deja MA, Grayburn PA, Sun B, Rao V, She L, Krejca M, Jain AR, Chua Y, Daly R, Senni M, Mokrzycki K, Menicanti L, Oh JK, Michler R, Wróbel K, Lamy A, Velazquez EJ, Lee KL, Jones RH. Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial. Circulation 2012, 125: 2639-2648. PMID: 22553307, PMCID: PMC3776601, DOI: 10.1161/circulationaha.111.072256.Peer-Reviewed Original ResearchConceptsSevere mitral regurgitationMild mitral regurgitationMitral regurgitationMitral valve repairTrace mitral regurgitationMitral surgeryMedical therapyValve repairIschemic Heart Failure (STICH) trialCoronary artery bypassHeart Failure TrialPrimary end pointLeft ventricular dysfunctionCoronary artery diseaseModerate mitral regurgitationBaseline prognostic variablesIschemic mitral regurgitationArtery bypassRandomized patientsVentricular dysfunctionHazard ratioArtery diseaseEjection fractionMedical armSurgical treatmentCore Lab Analysis of Baseline Echocardiographic Studies in the STICH Trial and Recommendation for Use of Echocardiography in Future Clinical Trials
Oh JK, Pellikka PA, Panza JA, Biernat J, Attisano T, Manahan BG, Wiste HJ, Lin G, Lee K, Miller FA, Stevens S, Sopko G, She L, Velazquez EJ, Investigators S. Core Lab Analysis of Baseline Echocardiographic Studies in the STICH Trial and Recommendation for Use of Echocardiography in Future Clinical Trials. Journal Of The American Society Of Echocardiography 2012, 25: 327-336. PMID: 22227341, PMCID: PMC3310914, DOI: 10.1016/j.echo.2011.12.002.Peer-Reviewed Original ResearchConceptsEjection fractionEffective regurgitant orifice areaRegurgitant orifice areaIschemic cardiomyopathyClinical practiceVentricular end-systolic volume indexPulmonary artery systolic pressureEnd-systolic volume indexLeast moderate mitral regurgitationOrifice areaBaseline echocardiographic examinationBaseline echocardiographic findingsBaseline echocardiographic studyCore lab analysisCoronary artery bypassIschemic heart failureMean ejection fractionCoronary artery diseaseModerate mitral regurgitationUse of echocardiographyMitral inflow velocityEchocardiography core laboratoryFuture clinical trialsCore laboratory analysisMitral regurgitation severity