2017
Prevalence and Outcomes of Left‐Sided Valvular Heart Disease Associated With Chronic Kidney Disease
Samad Z, Sivak JA, Phelan M, Schulte PJ, Patel U, Velazquez EJ. Prevalence and Outcomes of Left‐Sided Valvular Heart Disease Associated With Chronic Kidney Disease. Journal Of The American Heart Association 2017, 6: e006044. PMID: 29021274, PMCID: PMC5721834, DOI: 10.1161/jaha.117.006044.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAortic ValveAortic Valve StenosisComorbidityDatabases, FactualEchocardiographyFemaleGlomerular Filtration RateHumansKaplan-Meier EstimateKidneyMaleMiddle AgedMitral ValveMitral Valve InsufficiencyNorth CarolinaPrevalencePrognosisProportional Hazards ModelsRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsConceptsChronic kidney diseaseFive-year survival estimatesNon-CKD patientsCKD patientsMitral regurgitationMR severityKidney diseaseSurvival estimatesCoronary artery bypassGlomerular filtration ratePercutaneous coronary interventionSevere mitral regurgitationValvular heart diseaseSerum creatinine valuesAdverse prognostic markerRegurgitant valve lesionsIndex echocardiogramSevere ASArtery bypassIntervention patientsValve lesionsValve surgeryCoronary interventionHazard ratioHeart failure
2016
Effect of single and dual renin-angiotensin blockade on stroke in patients with and without diabetes in VALIANT
Abdul-Rahim AH, Docherty KF, Skali H, Køber L, Dickstein K, Maggioni AP, Mareev V, Zannad F, Velazquez EJ, Califf RM, Pfeffer MA, Solomon SD, Lees KR, McMurray JJ. Effect of single and dual renin-angiotensin blockade on stroke in patients with and without diabetes in VALIANT. European Stroke Journal 2016, 1: 93-100. PMID: 31008270, PMCID: PMC6301225, DOI: 10.1177/2396987316646025.Peer-Reviewed Original ResearchAngiotensin receptor blockersRisk of strokeAcute myocardial infarctionMyocardial infarctionReceptor blockersDual renin-angiotensin system blockadeEnzyme inhibitorsDual renin-angiotensin blockadeRenin-angiotensin system blockadeAcute Myocardial Infarction trialCox proportional hazards regressionRenin-angiotensin blockadeMyocardial Infarction trialRate of strokeVentricular systolic dysfunctionProportional hazards regressionRenin inhibitor aliskirenSystem blockadeSystolic dysfunctionHazard ratioHeart failureTreatment groupsPatientsDiabetesStroke
2014
Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records
Bloomfield GS, Hogan JW, Keter A, Holland TL, Sang E, Kimaiyo S, Velazquez EJ. Blood pressure level impacts risk of death among HIV seropositive adults in Kenya: a retrospective analysis of electronic health records. BMC Infectious Diseases 2014, 14: 284. PMID: 24886474, PMCID: PMC4046023, DOI: 10.1186/1471-2334-14-284.Peer-Reviewed Original ResearchConceptsSystolic blood pressureLower blood pressureHigher systolic blood pressureCardiovascular risk factorsBlood pressure levelsBlood pressureHigh blood pressureHigher mortality riskMortality rateHazard ratioRisk factorsIncidence rateRetrospective analysisMortality riskLarge HIV treatment programHuman immunodeficiency virus (HIV) infectionNormal systolic blood pressureProportional hazards regression modelsCox proportional hazards modelAdvanced HIV diseaseNon-communicable causeHIV-seropositive individualsHIV-seropositive adultsImmunodeficiency virus infectionHIV treatment programs
2012
Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial
Deja MA, Grayburn PA, Sun B, Rao V, She L, Krejca M, Jain AR, Chua Y, Daly R, Senni M, Mokrzycki K, Menicanti L, Oh JK, Michler R, Wróbel K, Lamy A, Velazquez EJ, Lee KL, Jones RH. Influence of Mitral Regurgitation Repair on Survival in the Surgical Treatment for Ischemic Heart Failure Trial. Circulation 2012, 125: 2639-2648. PMID: 22553307, PMCID: PMC3776601, DOI: 10.1161/circulationaha.111.072256.Peer-Reviewed Original ResearchConceptsSevere mitral regurgitationMild mitral regurgitationMitral regurgitationMitral valve repairTrace mitral regurgitationMitral surgeryMedical therapyValve repairIschemic Heart Failure (STICH) trialCoronary artery bypassHeart Failure TrialPrimary end pointLeft ventricular dysfunctionCoronary artery diseaseModerate mitral regurgitationBaseline prognostic variablesIschemic mitral regurgitationArtery bypassRandomized patientsVentricular dysfunctionHazard ratioArtery diseaseEjection fractionMedical armSurgical treatment
2009
Chronic obstructive pulmonary disease is an independent predictor of death but not atherosclerotic events in patients with myocardial infarction: analysis of the Valsartan in Acute Myocardial Infarction Trial (VALIANT)
Hawkins NM, Huang Z, Pieper KS, Solomon SD, Kober L, Velazquez EJ, Swedberg K, Pfeffer MA, McMurray JJ, Maggioni AP, Investigators F. Chronic obstructive pulmonary disease is an independent predictor of death but not atherosclerotic events in patients with myocardial infarction: analysis of the Valsartan in Acute Myocardial Infarction Trial (VALIANT). European Journal Of Heart Failure 2009, 11: 292-298. PMID: 19176539, PMCID: PMC2645058, DOI: 10.1093/eurjhf/hfp001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiotensin II Type 1 Receptor BlockersAntihypertensive AgentsAtherosclerosisCause of DeathConfidence IntervalsDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionOdds RatioPrognosisProportional Hazards ModelsProspective StudiesPulmonary Disease, Chronic ObstructiveSurvival RateTetrazolesTime FactorsValineValsartanConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseAcute Myocardial Infarction trialMyocardial Infarction trialPulmonary diseaseAcute myocardial infarctionAtherosclerotic eventsMyocardial infarctionIndependent predictorsCV outcomesHazard ratioNon-fatal clinical eventsNon-CV deathAdjusted hazard ratioMajor cardiovascular eventsHigh-risk patientsRisk of deathProportional hazards modelMode of deathMedian followCardiovascular eventsCause mortalityAirway diseaseMultivariate adjustmentUnadjusted risk
2006
Extent of coronary artery disease as a predictor of outcomes in acute myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
Janardhanan R, Kenchaiah S, Velazquez EJ, Park Y, McMurray JJ, Weaver WD, Finn PV, White HD, Marin-Neto JA, O'Connor C, Pfeffer MA, Califf RM, Solomon SD, Investigators F. Extent of coronary artery disease as a predictor of outcomes in acute myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. American Heart Journal 2006, 152: 183-189. PMID: 16824854, DOI: 10.1016/j.ahj.2005.11.013.Peer-Reviewed Original ResearchConceptsExtent of CADCoronary artery diseaseAcute myocardial infarctionHeart failureCV outcomesMyocardial infarctionCause mortalityArtery diseaseSeverity of CADVentricular systolic dysfunctionAdverse CV outcomesHigh-risk patientsIndependent risk factorSingle-vessel diseasePredictors of outcomeProportional hazards modelCoronary angiography dataCaptopril monotherapyValsartan monotherapyCardiovascular outcomesSystolic dysfunctionVentricular dysfunctionHazard ratioEjection fractionPoor outcome
2004
An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry
Velazquez EJ, Francis GS, Armstrong PW, Aylward PE, Diaz R, O'Connor CM, White HD, Henis M, Rittenhouse LM, Kilaru R, van Gilst W, Ertl G, Maggioni AP, Spac J, Weaver WD, Rouleau JL, McMurray JJ, Pfeffer MA, Califf RM. An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry. European Heart Journal 2004, 25: 1911-1919. PMID: 15522470, DOI: 10.1016/j.ehj.2004.08.006.Peer-Reviewed Original ResearchConceptsHospital heart failureVentricular systolic dysfunctionHeart failureMyocardial infarctionBaseline variablesSystolic dysfunctionMI patientsConsecutive MI patientsBaseline risk factorsHospital mortality rateMI populationAcute myocardial infarctionEarly myocardial infarctionLong-term riskHospital mortalityCardiovascular eventsHospital deathHazard ratioLonger hospitalisationBaseline presenceMedical therapySuch patientsContemporary incidenceMore complicationsRisk factors