2012
Embryo assessment strategies and their validation for clinical use
Uyar A, Seli E. Embryo assessment strategies and their validation for clinical use. Current Opinion In Obstetrics & Gynecology 2012, 24: 141-150. PMID: 22487726, DOI: 10.1097/gco.0b013e328352cd17.Peer-Reviewed Original Research
2010
Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome
Seli E, Bruce C, Botros L, Henson M, Roos P, Judge K, Hardarson T, Ahlström A, Harrison P, Henman M, Go K, Acevedo N, Siques J, Tucker M, Sakkas D. Receiver operating characteristic (ROC) analysis of day 5 morphology grading and metabolomic Viability Score on predicting implantation outcome. Journal Of Assisted Reproduction And Genetics 2010, 28: 137-144. PMID: 21063765, PMCID: PMC3059520, DOI: 10.1007/s10815-010-9501-9.Peer-Reviewed Original ResearchConceptsSingle embryo transferFetal cardiac activityMorphologic gradingViability scoreWeeks of gestationPregnancy outcomesIVF outcomesIVF centerCharacteristic analysisMorphology gradingImplantation outcomesEmbryo transferDay 5ResultsThe areaConclusionsOur findingsPregnancyEmbryo culture medium samplesCardiac activityComposite scoreScoresCleavage rateOutcomesCulture medium samplesEmbryo morphologyGradingPerspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction.
Aydiner F, Yetkin CE, Seli E. Perspectives on emerging biomarkers for non-invasive assessment of embryo viability in assisted reproduction. 2010, 10: 206-15. PMID: 20196727, DOI: 10.2174/156652410790963349.Peer-Reviewed Original Research
2008
Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics
Bromer JG, Seli E. Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics. Current Opinion In Obstetrics & Gynecology 2008, 20: 234-241. PMID: 18460937, DOI: 10.1097/gco.0b013e3282fe723d.Peer-Reviewed Original ResearchConceptsHigher multiple pregnancy rateEmbryo assessmentMultiple pregnancy rateReproductive technology cyclesLower implantation rateReproductive technologiesAssessment of glucoseCleavage rateImplantation rateUse of metabolomicsPregnancy rateRole of metabolomicsEmbryo culture mediumEmbryo viabilityUseful adjunctGood embryosAmino acid metabolismReproductive medicineMetabolomic profilingTechnology cyclesAcid metabolismOxygen consumptionOverview of studiesEmbryo metabolismProteomic profiling