2023
Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Akintoye E, Saijo Y, Braghieri L, Badwan O, Patel H, Dabbagh M, El Dahdah J, Jellis C, Desai M, Rodriguez L, Grimm R, Griffin B, Popović Z. Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. Journal Of The American College Of Cardiology 2023, 81: 1474-1487. PMID: 37045517, DOI: 10.1016/j.jacc.2023.02.037.Peer-Reviewed Original ResearchConceptsSmaller LV volumesAdverse eventsAortic regurgitationBody surface areaOlder patientsYounger patientsLV volumesImpact of ageLV remodelingSerial evaluationLV end-systolic volumeLV end-diastolic volumeSevere aortic regurgitationChronic aortic regurgitationLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volumeLower LV volumesAdult patientsConsecutive patientsMain endpointVentricular dimensionsVentricular remodelingCurrent guidelinesPatientsEcho Doppler Parameters of Diastolic Function
Anthony C, Akintoye E, Wang T, Klein A. Echo Doppler Parameters of Diastolic Function. Current Cardiology Reports 2023, 25: 235-247. PMID: 36821063, DOI: 10.1007/s11886-023-01844-3.Peer-Reviewed Original ResearchMeSH KeywordsDiastoleEchocardiographyEchocardiography, DopplerHumansVentricular Dysfunction, LeftVentricular Function, LeftConceptsDiastolic dysfunctionEcho-Doppler parametersDiastolic functionDoppler parametersEvaluation of DDAbnormal diastolic functionDoppler echocardiography techniquesLV filling pressureModest diagnostic performanceSignificant inter-observer variabilityEchocardiographic parametersRecent guidelinesAppropriate diagnosisFilling pressureInvasive measuresReviewThe purposeEchocardiography techniquesInter-observer variabilityEuropean AssociationCardiovascular imagingDiagnostic performanceEchocardiographyAmerican SocietyGuideline documentsDiagnosis
2022
Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation
Akintoye E, Wang T, Nakhla M, Ali A, Fava A, Akyuz K, Popovic Z, Pettersson G, Gillinov A, Xu B, Griffin B, Desai M. Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation. JACC Cardiovascular Imaging 2022, 16: 13-24. PMID: 36274042, DOI: 10.1016/j.jcmg.2022.08.004.Peer-Reviewed Original ResearchConceptsTricuspid regurgitationMedian survival timeRisk factorsAsymptomatic patientsEchocardiographic parametersSurvival timeEarly interventionOptimal timingRight heart parametersSymptomatic tricuspid regurgitationSignificant tricuspid regurgitationFree wall strainHigh operative mortalitySex-matched cohortQuantitative echocardiographic assessmentKey prognostic markersCause mortalityOperative mortalityTR patientsEchocardiographic assessmentLate presentationPoor outcomePrognostic utilityPrognostic valuePrognostic markerClinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation
Layoun H, Mentias A, Akintoye E, Matta M, Kanaan C, Daou R, Ramchand J, Burns D, Gillinov A, Bhattacharya S, Puri R, Collier P, Griffin B, Kapadia S, Harb S. Clinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation. Open Heart 2022, 9: e001996. PMID: 35383126, PMCID: PMC8984044, DOI: 10.1136/openhrt-2022-001996.Peer-Reviewed Original ResearchMeSH KeywordsAdultDilatationEchocardiographyFemaleHumansMaleMitral ValveMitral Valve InsufficiencyPrognosisConceptsSecondary mitral regurgitationAtrial dilationMitral regurgitationPrognostic implicationsSevere left atrial dilationSevere secondary mitral regurgitationLA reservoir strainLeft atrial dilationLeft ventricle dysfunctionPoor prognostic indicatorMV interventionVentricle dysfunctionMore diabetesAdult patientsTransthoracic echocardiographyEjection fractionIndependent predictorsAtrial fibrillationReservoir strainWorse prognosisPrognostic indicatorMR severityBetter outcomesFunctional alterationsPatients
2017
Early Prosthetic Valve Dysfunction Due to Bioprosthetic Valve Thrombosis The Role of Echocardiography
Egbe A, Pislaru S, Ali M, Khan A, Boler A, Schaff H, Akintoye E, Connolly H, Nkomo V, Pellikka P. Early Prosthetic Valve Dysfunction Due to Bioprosthetic Valve Thrombosis The Role of Echocardiography. JACC Cardiovascular Imaging 2017, 11: 951-958. PMID: 29055629, DOI: 10.1016/j.jcmg.2017.06.022.Peer-Reviewed Original ResearchConceptsProsthetic valve dysfunctionBioprosthetic valve thrombosisTransthoracic echocardiographyPVD diagnosisValve thrombosisValve implantationRetrospective case-control studyAcute disease processPatients ages 61Role of echocardiographyRoutine transthoracic echocardiographyCase-control studyMen 61Symptomatic deteriorationMost patientsValve dysfunctionAppropriate therapyInitial diagnosisSF patientsBioprosthetic valvesTimely diagnosisPatient's conditionBaseline gradientAge 61Disease processRole of diastolic function indices in the risk stratification of patients with mixed aortic valve disease
Egbe A, Khan A, Boler A, Said S, Geske J, Miranda W, Akintoye E, Connolly H, Warnes C, Oh J. Role of diastolic function indices in the risk stratification of patients with mixed aortic valve disease. European Heart Journal - Cardiovascular Imaging 2017, 19: 668-674. PMID: 28655164, DOI: 10.1093/ehjci/jex148.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnalysis of VarianceAortic Valve InsufficiencyAortic Valve StenosisAsymptomatic DiseasesCohort StudiesConfidence IntervalsDiastoleEchocardiographyFemaleHumansMaleMiddle AgedMonitoring, PhysiologicPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentSex FactorsStroke VolumeSurvival RateUnited StatesConceptsAortic valve replacementCardiovascular adverse eventsRelative wall thicknessMixed aortic valve diseaseDiastolic function indicesAortic valve diseaseCardiac deathRisk stratificationValve diseaseFunction IndexHigh-risk patient subsetsPost-operative risk stratificationSevere left ventricular dysfunctionAtrial volume indexHeart failure hospitalizationTricuspid regurgitation velocityEarly diastolic velocityLeft ventricular dysfunctionMultivariable risk factorsAsymptomatic patientsCardiovascular morbidityFailure hospitalizationPrimary endpointSecondary endpointsVentricular dysfunctionPrevalence and predictors of intracranial aneurysms in patients with bicuspid aortic valve
Egbe A, Padang R, Brown R, Khan A, Luis S, Huston J, Akintoye E, Connolly H. Prevalence and predictors of intracranial aneurysms in patients with bicuspid aortic valve. Heart 2017, 103: 1508. PMID: 28596303, DOI: 10.1136/heartjnl-2016-311076.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overAortic ValveBicuspid Aortic Valve DiseaseBrainEchocardiographyFemaleFollow-Up StudiesForecastingHeart Valve DiseasesHumansIntracranial AneurysmMagnetic Resonance AngiographyMaleMiddle AgedMinnesotaPrevalenceRetrospective StudiesRisk FactorsSex DistributionConceptsCoarctation of aortaBicuspid aortic valveLeft cusp fusionIntracranial aneurysmsCusp fusionAortic valveFemale genderBrain MR angiographyStudy mean ageAge tertilesRetrospective reviewCoil embolisationRisk factorsMayo ClinicHigh prevalenceAge 41General populationPatientsMR angiographyPrevalenceAneurysmsAgeRiskYearsEmbolisation