2018
Venous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment
Egbe A, Reddy Y, Khan A, Al-Otaibi M, Akintoye E, Obokata M, Borlaug B. Venous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment. International Journal Of Cardiology 2018, 271: 312-316. PMID: 30223363, PMCID: PMC6146405, DOI: 10.1016/j.ijcard.2018.05.039.Peer-Reviewed Original ResearchConceptsPulmonary vascular resistance indexCentral venous pressureSystemic venous congestionPulmonary vascular functionFontan patientsVenous congestionFontan circulationVascular functionElevated pulmonary vascular resistance indexAdult Fontan patientsVascular resistance indexPulmonary blood flowSub-pulmonary ventricleCongenital heart diseaseLow-level elevationsPulmonary vascular structureFontan groupFontan populationAntiplatelet therapyCause mortalityCardiac catheterizationComposite endpointVenous pressureMulticenter studyAdverse outcomes
2017
Mechanism for temporal changes in exercise capacity after Fontan palliation: Role of Doppler echocardiography
Egbe A, Khan A, Miranda W, Ammash N, Warnes C, Said S, Taggart N, Akintoye E, Veldtman G, Connolly H. Mechanism for temporal changes in exercise capacity after Fontan palliation: Role of Doppler echocardiography. American Heart Journal 2017, 196: 144-152. PMID: 29421006, DOI: 10.1016/j.ahj.2017.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAge FactorsCohort StudiesDouble Outlet Right VentricleEchocardiography, DopplerExercise TestExercise ToleranceFollow-Up StudiesFontan ProcedureHeart Defects, CongenitalHumansMaleMichiganOxygen ConsumptionPulmonary AtresiaRetrospective StudiesTime FactorsTreatment OutcomeTricuspid AtresiaYoung AdultConceptsCardiopulmonary exercise testTransthoracic echocardiogramLV function indicesFontan palliationExercise capacityChronotropic indexFunction IndexLeft ventricleAdult Fontan patientsFontan conversion operationSystemic left ventriclePeak oxygen consumptionSerial transthoracic echocardiogramsFontan patientsFontan conversionDoppler echocardiographyRetrospective reviewDoppler hemodynamicsMean ageHemodynamic mechanismsExercise testMayo ClinicCPET dataPatientsTemporal improvementRole of Doppler echocardiography for cardiac output assessment in Fontan patients
Egbe A, Khan A, Khan S, Anavekar N, Said S, Young P, Akintoye E, Miranda W, Al-Otaibi M, Veldtman G, Connolly H. Role of Doppler echocardiography for cardiac output assessment in Fontan patients. American Heart Journal 2017, 195: 91-98. PMID: 29224651, DOI: 10.1016/j.ahj.2017.09.014.Peer-Reviewed Original ResearchConceptsStroke volume indexSystemic left ventricleSystemic right ventricleFontan failureRight ventricleLeft ventricleFontan patientsTransthoracic echocardiographyLV patientsProtein-losing enteropathyCardiac output assessmentAge 17 yearsMean age 17 yearsHeart transplantationCardiac thrombusFontan conversionEjection fractionHeart failureDoppler echocardiographyPatientsVolume indexCMRIML/CirrhosisEchocardiographyOutcomes of cardiac pacing in adult patients after a Fontan operation
Egbe A, Huntley G, Connolly H, Ammash N, Deshmukh A, Khan A, Said S, Akintoye E, Warnes C, Kapa S. Outcomes of cardiac pacing in adult patients after a Fontan operation. American Heart Journal 2017, 194: 92-98. PMID: 29223440, DOI: 10.1016/j.ahj.2017.08.019.Peer-Reviewed Original ResearchConceptsDevice-related complicationsCardiovascular adverse eventsAdult Fontan patientsFontan patientsEndocardial leadsFontan operationPacemaker implantationRisk factorsEpicardial leadsCardiac pacingLead failureDevice-related infectionsReintervention rateAdult patientsAdverse eventsHeart transplantRetrospective reviewVenous thrombosisCardiac perforationMayo ClinicReinterventionPatientsLead recallDual chamberPacingPredictors of procedural complications in adult Fontan patients undergoing non-cardiac procedures
Egbe A, Khan A, Ammash N, Barbara D, Oliver W, Said S, Akintoye E, Warnes C, Connolly H. Predictors of procedural complications in adult Fontan patients undergoing non-cardiac procedures. Heart 2017, 103: 1813. PMID: 28501797, DOI: 10.1136/heartjnl-2016-311039.Peer-Reviewed Original ResearchConceptsNon-cardiac proceduresFontan patientsProcedural complicationsHeart diseaseRisk factorsAdult Fontan patientsAcute kidney injuryDialysis catheter placementMultivariable risk factorsIntensive care unitMultidisciplinary care approachCongenital heart diseaseBiventricular circulationFontan groupIntravenous diureticsAnesthesia typeCause mortalityKidney injuryAdult patientsFontan operationMinimal sedationBlood transfusionHeart failureUnplanned hospitalisationCare unitCardiopulmonary exercise test in adults with prior Fontan operation: The prognostic value of serial testing
Egbe A, Driscoll D, Khan A, Said S, Akintoye E, Berganza F, Connolly H. Cardiopulmonary exercise test in adults with prior Fontan operation: The prognostic value of serial testing. International Journal Of Cardiology 2017, 235: 6-10. PMID: 28284501, DOI: 10.1016/j.ijcard.2017.02.140.Peer-Reviewed Original ResearchConceptsSerial cardiopulmonary exercise testsCardiovascular adverse eventsCardiopulmonary exercise testPercentage points/yearPoints/yearFontan operationPeak VOExercise testBaseline cardiopulmonary exercise testBaseline peak oxygen consumptionAdult Fontan patientsAdult Fontan populationPrior Fontan operationPeak oxygen consumptionPeak heart rateFontan populationFontan palliationFontan patientsPeak exerciseAdverse eventsCardiac surgeryRetrospective reviewPrognostic valueInclusion criteriaSerial testing