2023
Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Akintoye E, Saijo Y, Braghieri L, Badwan O, Patel H, Dabbagh M, El Dahdah J, Jellis C, Desai M, Rodriguez L, Grimm R, Griffin B, Popović Z. Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. Journal Of The American College Of Cardiology 2023, 81: 1474-1487. PMID: 37045517, DOI: 10.1016/j.jacc.2023.02.037.Peer-Reviewed Original ResearchConceptsSmaller LV volumesAdverse eventsAortic regurgitationBody surface areaOlder patientsYounger patientsLV volumesImpact of ageLV remodelingSerial evaluationLV end-systolic volumeLV end-diastolic volumeSevere aortic regurgitationChronic aortic regurgitationLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volumeLower LV volumesAdult patientsConsecutive patientsMain endpointVentricular dimensionsVentricular remodelingCurrent guidelinesPatients
2022
Rilonacept for the treatment of recurrent pericarditis
Fava A, Reyaldeen R, Presti S, Goyal A, Akintoye E, Hughes D, Klein A. Rilonacept for the treatment of recurrent pericarditis. Expert Opinion On Biological Therapy 2022, 22: 7-16. PMID: 34757872, DOI: 10.1080/14712598.2022.2005024.Peer-Reviewed Original ResearchConceptsRecurrent pericarditisC-reactive proteinClinical trialsUpper respiratory tract infectionSafety of rilonaceptCommon adverse eventsRespiratory tract infectionsAvailable clinical trialsInjection site reactionsRapid clinical responseValuable therapeutic optionGood safety profilePromising new therapyIL-1β signalingDimeric fusion proteinGlucocorticoid-dependent diseasesAdverse eventsClinical responseTherapy durationTract infectionsSuccessful weaningRecurrence rateSafety profileTherapeutic optionsFuture trials
2021
Prognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices
Ali A, Akintoye E, Duque E, Kshetri R, Shetty S, Sharma U, Johnson C, Panos A, Briasoulis A, Alvarez P. Prognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices. ASAIO Journal 2021, 68: 524-530. PMID: 34352812, DOI: 10.1097/mat.0000000000001524.Peer-Reviewed Original ResearchConceptsNT-pro BNP concentrationHF hospitalizationBNP concentrationsVentricular assist devicePrognostic implicationsN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideAssist deviceHeart failure hospitalizationNT-pro BNPFailure hospitalizationIndex hospitalizationAdverse eventsLVAD implantationConsecutive patientsAmbulatory patientsNatriuretic peptideRetrospective studyHospitalizationAmbulatory settingPatientsMonth baselineMonthsDeathUnit increase
2019
Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis
Egbe A, Adigun R, Anand V, West C, Montori V, Murad M, Akintoye E, Osman K, Connolly H. Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis. Canadian Journal Of Cardiology 2019, 35: 1784-1790. PMID: 31732195, DOI: 10.1016/j.cjca.2019.07.634.Peer-Reviewed Original ResearchConceptsCardiovascular adverse eventsLV ejection fractionLeft ventricular systolic dysfunctionLV systolic dysfunctionVentricular systolic dysfunctionSystolic dysfunctionHazard ratioLV systolic functionSudden cardiac deathNew treatment optionsClinical risk stratificationConfidence intervalsTetralogy of FallotVentricular tachycardia eventsRandom-effects modelCardiovascular outcomesAdverse eventsSystolic functionCardiac deathEjection fractionIndependent predictorsRisk stratificationPrognostic implicationsTreatment optionsTachycardia events
2018
Acute Myocardial Infarction Outcomes in Systemic Lupus Erythematosus (from the Nationwide Inpatient Sample)
Ando T, Adegbala O, Akintoye E, Ashraf S, Briasoulis A, Takagi H, Afonso L. Acute Myocardial Infarction Outcomes in Systemic Lupus Erythematosus (from the Nationwide Inpatient Sample). The American Journal Of Cardiology 2018, 123: 227-232. PMID: 30424870, DOI: 10.1016/j.amjcard.2018.09.043.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionSystemic lupus erythematosusPropensity-matched cohortMajor adverse eventsHospital mortalityTherapy ratesRevascularization strategyNSTEMI admissionsHospital outcomesAdverse eventsLupus erythematosusMyocardial infarctionOdds ratioAcute myocardial infarction (AMI) outcomesMajor adverse clinical eventsCoronary artery bypass surgeryMyocardial infarction outcomesNon-SLE cohortAcute coronary syndromeArtery bypass surgeryNationwide inpatient databaseAdverse clinical eventsElevation myocardial infarctionPercutaneous coronary interventionAcute myocardial infarction
2017
Statins and contrast-induced nephropathy: a systematic review and meta-analysis.
Briasoulis A, Pala M, Telila T, Merid O, Akintoye E, Vogiatzi G, Oikonomou E, Tousoulis D. Statins and contrast-induced nephropathy: a systematic review and meta-analysis. Current Pharmaceutical Design 2017, 23: 7141-7148. PMID: 28914202, DOI: 10.2174/1381612823666170913170527.Peer-Reviewed Original ResearchContrast-induced nephropathySerum creatininePrevention of CINSystematic reviewAdequate intravenous hydrationMain prevention strategyTarget vessel occlusionAcute kidney injuryHospital myocardial infarctionLow-risk patientsNormal renal functionSerum creatinine clearanceEarly adverse eventsHigh-risk populationNoninvasive coronary angiographyCIN incidenceCIN variesIntravenous hydrationKidney injuryAdverse eventsCreatinine clearanceRenal functionStatin administrationContrast loadCoronary angiographyOutcomes of cardiac pacing in adult patients after a Fontan operation
Egbe A, Huntley G, Connolly H, Ammash N, Deshmukh A, Khan A, Said S, Akintoye E, Warnes C, Kapa S. Outcomes of cardiac pacing in adult patients after a Fontan operation. American Heart Journal 2017, 194: 92-98. PMID: 29223440, DOI: 10.1016/j.ahj.2017.08.019.Peer-Reviewed Original ResearchConceptsDevice-related complicationsCardiovascular adverse eventsAdult Fontan patientsFontan patientsEndocardial leadsFontan operationPacemaker implantationRisk factorsEpicardial leadsCardiac pacingLead failureDevice-related infectionsReintervention rateAdult patientsAdverse eventsHeart transplantRetrospective reviewVenous thrombosisCardiac perforationMayo ClinicReinterventionPatientsLead recallDual chamberPacingCardiopulmonary exercise test in adults with prior Fontan operation: The prognostic value of serial testing
Egbe A, Driscoll D, Khan A, Said S, Akintoye E, Berganza F, Connolly H. Cardiopulmonary exercise test in adults with prior Fontan operation: The prognostic value of serial testing. International Journal Of Cardiology 2017, 235: 6-10. PMID: 28284501, DOI: 10.1016/j.ijcard.2017.02.140.Peer-Reviewed Original ResearchConceptsSerial cardiopulmonary exercise testsCardiovascular adverse eventsCardiopulmonary exercise testPercentage points/yearPoints/yearFontan operationPeak VOExercise testBaseline cardiopulmonary exercise testBaseline peak oxygen consumptionAdult Fontan patientsAdult Fontan populationPrior Fontan operationPeak oxygen consumptionPeak heart rateFontan populationFontan palliationFontan patientsPeak exerciseAdverse eventsCardiac surgeryRetrospective reviewPrognostic valueInclusion criteriaSerial testing