Featured Publications
Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J
Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen M, Naganawa M, Toyonaga T, Nabulsi NB, Vander Wyk B, Arnsten AFT, Huang Y, Carson RE, van Dyck C. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J. Alzheimer's & Dementia 2022, 18: 2527-2536. PMID: 35174954, PMCID: PMC9381645, DOI: 10.1002/alz.12582.Peer-Reviewed Original ResearchConceptsSynaptic densityEarly Alzheimer's diseaseAlzheimer's diseaseCognitive performanceMajor pathological correlateGray matter volumePositron emission tomography (PET) imagingEmission Tomography ImagingPET imaging studiesIndividual cognitive domainsNeuropathologic studiesSignificant positive associationSynapse lossSynaptic alterationsPathological correlatesNeuropsychological test performanceMatter volumeCognitive impairmentSignificant associationImaging studiesDiseaseTomography imagingGlobal cognitionStrongest predictorPositive association
2019
Openness Declines in Advance of Death in Late Adulthood
Sharp ES, Beam CR, Reynolds CA, Gatz M. Openness Declines in Advance of Death in Late Adulthood. Psychology And Aging 2019, 34: 124-138. PMID: 30667240, PMCID: PMC6441733, DOI: 10.1037/pag0000328.Peer-Reviewed Original Research
2018
Effects of Normative Adjustments to the Montreal Cognitive Assessment
Pugh EA, Kemp EC, van Dyck CH, Mecca AP, Sharp ES, Initiative F. Effects of Normative Adjustments to the Montreal Cognitive Assessment. American Journal Of Geriatric Psychiatry 2018, 26: 1258-1267. PMID: 30314940, PMCID: PMC6779033, DOI: 10.1016/j.jagp.2018.09.009.Peer-Reviewed Original Research
2011
Relationship Between Education and Dementia
Sharp ES, Gatz M. Relationship Between Education and Dementia. Alzheimer Disease & Associated Disorders 2011, 25: 289-304. PMID: 21750453, PMCID: PMC3193875, DOI: 10.1097/wad.0b013e318211c83c.Peer-Reviewed Original Research
2010
Cognitive Engagement and Cognitive Aging: Is Openness Protective?
Sharp ES, Reynolds CA, Pedersen NL, Gatz M. Cognitive Engagement and Cognitive Aging: Is Openness Protective? Psychology And Aging 2010, 25: 60-73. PMID: 20230128, PMCID: PMC2853722, DOI: 10.1037/a0018748.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAlzheimer DiseaseCardiovascular DiseasesCognition DisordersDiseases in TwinsEducational StatusExploratory BehaviorFemaleHumansInterpersonal RelationsLeisure ActivitiesLongitudinal StudiesMaleMiddle AgedModels, PsychologicalMotivationSocial BehaviorStatistics as TopicSurveys and QuestionnairesTemperamentConceptsCognitive performanceSwedish Adoption/Twin StudyHigher cognitive test scoresLatent growth curve modelsCognitive test scoresGrowth curve modelsVerbal abilityCognitive agingCognitive domainsCognitive engagementCognitive testsSpatial abilityProcessing speedCognitive declineTest scoresLongitudinal trajectoriesHigh opennessTwin studiesCurve modelLongitudinal changesGlobal scoreOpennessDaily livingIndividualsMemory