Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
Annibali D, Whitfield J, Favuzzi E, Jauset T, Serrano E, Cuartas I, Redondo-Campos S, Folch G, Gonzàlez-Juncà A, Sodir N, Massó-Vallés D, Beaulieu M, Swigart L, Mc Gee M, Somma M, Nasi S, Seoane J, Evan G, Soucek L. Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis. Nature Communications 2014, 5: 4632. PMID: 25130259, PMCID: PMC4143920, DOI: 10.1038/ncomms5632.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAstrocytomaBrain NeoplasmsCell Line, TumorCell ProliferationDisease Models, AnimalGlioblastomaGliomaHeterograftsHumansMiceMice, TransgenicMitosisProtein Tyrosine Phosphatase, Non-Receptor Type 1Proto-Oncogene Proteins c-mycUbiquitin-Activating EnzymesConceptsMYC inhibitionElevated MYC levelsPatient-derived tumorsAdult central nervous systemHuman glioblastoma cell linesCentral nervous systemFormation of multinucleated cellsPrimary tumorGlioblastoma cell linesStandard therapyOrthotopic xenograftsMYC levelsMouse modelIncreased apoptosisCancer therapyHuman tumorsMitotic catastropheTherapeutic strategiesHuman gliomasMYCTumorNervous systemInvasive astrocytomasGliomaCell lines