2023
The brain's polymath: Emerging roles of microglia throughout brain development
Wong F, Favuzzi E. The brain's polymath: Emerging roles of microglia throughout brain development. Current Opinion In Neurobiology 2023, 79: 102700. PMID: 36848726, DOI: 10.1016/j.conb.2023.102700.Peer-Reviewed Original ResearchConceptsPotential contribution of microgliaResident brain immune cellsInfluence neuronal connectivityBrain immune cellsDevelopment of functional networksContribution of microgliaNeuronal circuit developmentElements of neural circuitsImmune cellsNeuronal activityExtracellular matrixSynapse pruningNeuron numberPrune synapsesMicrogliaBrain developmentNeuronal connectivityNeural circuitsBrain wiringCircuit developmentFunctional networksBrainIntegrative viewCircuit wiringIncreased understanding
2022
Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity
Gesuita L, Cavaccini A, Argunsah A, Favuzzi E, Ibrahim L, Stachniak T, De Gennaro M, Utz S, Greter M, Karayannis T. Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity. Cell Reports 2022, 40: 111209. PMID: 35977514, PMCID: PMC9396528, DOI: 10.1016/j.celrep.2022.111209.Peer-Reviewed Original Research
2021
GABA-receptive microglia selectively sculpt developing inhibitory circuits
Favuzzi E, Huang S, Saldi G, Binan L, Ibrahim L, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi S, Bonneau R, Datta S, Stevens B, Fishell G. GABA-receptive microglia selectively sculpt developing inhibitory circuits. Cell 2021, 184: 4048-4063.e32. PMID: 34233165, PMCID: PMC9122259, DOI: 10.1016/j.cell.2021.06.018.Peer-Reviewed Original ResearchConceptsInhibitory cortical synapsesBrain wiringResident immune cellsMouse postnatal developmentBehavioral abnormalitiesImmune cellsInhibitory circuitsSynaptic refinementGlial cell typesExcitatory synapsesCortical synapsesPostnatal developmentMicrogliaSynapse typesInhibitory connectionsCell typesBrainRemodeling programSynapsesAbnormalitiesGABA
2019
Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
Favuzzi E, Deogracias R, Marques-Smith A, Maeso P, Jezequel J, Exposito-Alonso D, Balia M, Kroon T, Hinojosa A, F Maraver E, Rico B. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits. Science 2019, 363: 413-417. PMID: 30679375, DOI: 10.1126/science.aau8977.Peer-Reviewed Original ResearchConceptsCortical inhibitory circuitsInhibitory circuitsClasses of GABAergic interneuronsInvestigate transcriptional dynamicsClasses of interneuronsConnectivity patternsAxon initial segmentGABAergic interneuronsMammalian cerebral cortexTranscriptional dynamicsCortical interneuronsPyramidal cellsSynapse specificityPostnatal developmentInterneuron diversityInterneuronsCerebral cortexMolecular mechanismsConnectivity motifsSynaptic moleculesBrain functionMolecular programsNeuronal connectivityInformation processingFunctional networks
2018
Molecular diversity underlying cortical excitatory and inhibitory synapse development
Favuzzi E, Rico B. Molecular diversity underlying cortical excitatory and inhibitory synapse development. Current Opinion In Neurobiology 2018, 53: 8-15. PMID: 29704699, DOI: 10.1016/j.conb.2018.03.011.Peer-Reviewed Original Research