Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies
Fontvieille E, Viallon V, Recalde M, Cordova R, Jansana A, Peruchet-Noray L, Lennon H, Heath A, Aune D, Christakoudi S, Katzke V, Kaaks R, Inan-Eroglu E, Schulze M, Mellemkjær L, Tjønneland A, Overvad K, Farràs M, Petrova D, Amiano P, Chirlaque M, Moreno-Iribas C, Tin Tin S, Masala G, Sieri S, Ricceri F, Panico S, May A, Monninkhof E, Weiderpass E, Gunter M, Ferrari P, Freisling H. Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies. BMC Medicine 2023, 21: 418. PMID: 37993940, PMCID: PMC10666332, DOI: 10.1186/s12916-023-03114-z.Peer-Reviewed Original ResearchConceptsRisk due to interactionObesity-related cancersRisk of obesity-related cancersBody mass indexHigher body mass indexCardiometabolic diseasesJoint associationsHazard ratioCancer riskIncidence of obesity-related cancersJoint association of body mass indexCardiovascular diseaseConfidence intervalsRisk of overall cancerExcess risk due to interactionAssociation of body mass indexSurrogate measure of adiposityUK Biobank prospective cohortCategories of overweight/obesityUK Biobank (UKBAdditive interactionMass indexCardiometabolic disease statusParticipant data meta-analysisCancer risk reductionUltra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis
Morales-Berstein F, Biessy C, Viallon V, Goncalves-Soares A, Casagrande C, Hémon B, Kliemann N, Cairat M, Blanco Lopez J, Al Nahas A, Chang K, Vamos E, Rauber F, Bertazzi Levy R, Barbosa Cunha D, Jakszyn P, Ferrari P, Vineis P, Masala G, Catalano A, Sonestedt E, Borné Y, Katzke V, Bajracharya R, Agnoli C, Guevara M, Heath A, Radoï L, Mancini F, Weiderpass E, Huerta J, Sánchez M, Tjønneland A, Kyrø C, Schulze M, Skeie G, Lukic M, Braaten T, Gunter M, Millett C, Agudo A, Brennan P, Borges M, Richmond R, Richardson T, Davey Smith G, Relton C, Huybrechts I. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis. European Journal Of Nutrition 2023, 63: 377-396. PMID: 37989797, PMCID: PMC10899298, DOI: 10.1007/s00394-023-03270-1.Peer-Reviewed Original ResearchConceptsConsumption of ultra-processed foodsUltra-processed foodsWaist-to-hip ratioRisk of head and neck cancerUltra-processed food consumptionOesophageal adenocarcinoma riskEuropean Prospective InvestigationBody mass indexHead and neck cancerIncreased risk of HNCHigher consumption of ultra-processed foodsHead and neck cancer riskProspective InvestigationCancer and NutritionNegative control analysesOesophageal adenocarcinomaWaist-to-hipNegative control outcomesAssociated with greater riskMediation analysisNeck cancerAccidental deathEPIC participantsMass indexGreater risk