Ethnic Differences in the Association Between Age at Natural Menopause and Risk of Type 2 Diabetes Among Postmenopausal Women: A Pooled Analysis of Individual Data From 13 Cohort Studies.
Chung H, Dobson A, Hayashi K, Hardy R, Kuh D, Anderson D, van der Schouw Y, Greenwood D, Cade J, Demakakos P, Brunner E, Eastwood S, Sandin S, Weiderpass E, Mishra G. Ethnic Differences in the Association Between Age at Natural Menopause and Risk of Type 2 Diabetes Among Postmenopausal Women: A Pooled Analysis of Individual Data From 13 Cohort Studies. Diabetes Care 2023, 46: 2024-2034. PMID: 37747341, PMCID: PMC10696407, DOI: 10.2337/dc23-1209.Peer-Reviewed Original ResearchConceptsIncreased risk of T2DPremature ovarian insufficiencyRisk of T2DType 2 diabetesPooled individual-level dataCohort studyHazard ratioIncident type 2 diabetesRisk of type 2 diabetesEthnic groupsNatural menopauseChinese womenEarly menopauseIncreased riskYears of follow-upIndividual-level dataBirth yearEducation levelInvestigate associationsRisk estimatesOvarian insufficiencyPostmenopausal womenEthnic differencesRisk factorsPooled analysisAge at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women
Tschiderer L, Peters S, van der Schouw Y, van Westing A, Tong T, Willeit P, Seekircher L, Moreno‐Iribas C, Huerta J, Crous‐Bou M, Söderholm M, Schulze M, Johansson C, Själander S, Heath A, Macciotta A, Dahm C, Ibsen D, Pala V, Mellemkjær L, Burgess S, Wood A, Kaaks R, Katzke V, Amiano P, Rodriguez‐Barranco M, Engström G, Weiderpass E, Tjønneland A, Halkjær J, Panico S, Danesh J, Butterworth A, Onland‐Moret N. Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women. Journal Of The American Heart Association 2023, 12: e030280. PMID: 37681566, PMCID: PMC10547274, DOI: 10.1161/jaha.123.030280.Peer-Reviewed Original ResearchConceptsMendelian randomization analysisRisk of strokeStatistically significant associationRandomization analysisSignificant associationHistory of strokeEPIC-CVDPooled mean ageHigh risk of strokeUK BiobankYears younger ageBaseline ageHazard ratioStroke subtypesObservational studyPooled hazard ratioHemorrhagic strokeEarly menopauseYounger ageMean ageHigh riskMedian follow-upStrokeRegression analysisWomen