2015
Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge
Miller EJ, Calamaras T, Elezaby A, Sverdlov A, Qin F, Luptak I, Wang K, Sun X, Vijay A, Croteau D, Bachschmid M, Cohen RA, Walsh K, Colucci WS. Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge. Journal Of The American Heart Association 2015, 5: e002277. PMID: 26722122, PMCID: PMC4859355, DOI: 10.1161/jaha.115.002277.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsApoptosisApoptosis Regulatory ProteinsCaspase 3DiastoleDiet, High-FatDietary SucroseDisease Models, AnimalGenetic Predisposition to DiseaseHeterozygoteHypertrophy, Left VentricularMice, KnockoutMitochondria, HeartMyocardiumPhenotypeProtein Serine-Threonine KinasesSignal TransductionSystoleTime FactorsTumor Suppressor Protein p53Tumor Suppressor ProteinsVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingConceptsHigh-sucrose dietSystolic dysfunctionDiastolic dysfunctionLiver kinase B1Metabolic heart diseaseDietary excessHeart diseaseMyocardial hypertrophyDe novo appearanceControl dietRestrictive filling patternSevere diastolic dysfunctionLeft ventricular dilationMitochondrial dysfunctionMetabolic stressWild-type miceHigh-sucrose feedingNovo appearanceP53/PUMAMore hypertrophyDiastolic functionMyocardial dysfunctionVentricular hypertrophyVentricular dilationSevere mitochondrial dysfunction
2014
Preclinical Left Ventricular Diastolic Dysfunction in Metabolic Syndrome
Ayalon N, Gopal DM, Mooney DM, Simonetti JS, Grossman JR, Dwivedi A, Donohue C, Perez AJ, Downing J, Gokce N, Miller EJ, Liang CS, Apovian CM, Colucci WS, Ho JE. Preclinical Left Ventricular Diastolic Dysfunction in Metabolic Syndrome. The American Journal Of Cardiology 2014, 114: 838-842. PMID: 25084691, PMCID: PMC4162746, DOI: 10.1016/j.amjcard.2014.06.013.Peer-Reviewed Original ResearchConceptsHigher LA diameterLV diastolic dysfunctionVentricular diastolic dysfunctionDiastolic dysfunctionMetabolic syndromeLV massLA diameterLV hypertrophyYounger ageEarly risk factor modificationHigher left atrial diameterLeft ventricular diastolic dysfunctionAntihypertensive medication useLeft atrial diameterRisk factor modificationGender-adjusted analysesHigher LV massBody mass indexTissue Doppler imagingAtrial diameterDiastolic functionBlood pressureMedication useMass indexFactor modification
2012
The Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice
Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS. The Polyphenols Resveratrol and S17834 Prevent the Structural and Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice. Circulation 2012, 125: 1757-1764. PMID: 22388319, PMCID: PMC3354628, DOI: 10.1161/circulationaha.111.067801.Peer-Reviewed Original ResearchConceptsHFHS diet-fed miceDiet-fed miceMetabolic heart diseaseDiastolic dysfunctionLeft ventricular hypertrophyMyocardial oxidative stressVentricular hypertrophyHeart diseaseInterstitial fibrosisPlasma adiponectinInsulin resistanceProgressive left ventricular hypertrophyDiet-induced metabolic syndromeBeneficial effectsOxidative stressHomeostasis model assessmentMale C57BL/6J miceChronic hemodynamic overloadHFHS dietCardiovascular effectsSystolic functionDiabetes mellitusMetabolic syndromeConcomitant treatmentHemodynamic overload