Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis
Gillmore JD, Maurer MS, Falk RH, Merlini G, Damy T, Dispenzieri A, Wechalekar AD, Berk JL, Quarta CC, Grogan M, Lachmann HJ, Bokhari S, Castano A, Dorbala S, Johnson GB, Glaudemans AW, Rezk T, Fontana M, Palladini G, Milani P, Guidalotti PL, Flatman K, Lane T, Vonberg FW, Whelan CJ, Moon JC, Ruberg FL, Miller EJ, Hutt DF, Hazenberg BP, Rapezzi C, Hawkins PN. Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis. Circulation 2016, 133: 2404-2412. PMID: 27143678, DOI: 10.1161/circulationaha.116.021612.Peer-Reviewed Original ResearchConceptsCardiac ATTR amyloidosisBone scintigraphyCardiac transthyretin amyloidosisATTR amyloidosisMyocardial radiotracer uptakeRadiotracer uptakeTransthyretin amyloidosisMajority of patientsCardiac AL amyloidosisNoninvasive diagnostic criteriaMyocardial amyloid depositsPositive predictive valueHistological confirmationMulticenter studySpecialist centresMonoclonal gammopathyCardiac amyloidosisPromising therapyAL amyloidosisATTR amyloidDiagnostic criteriaAmyloid depositsFatal cardiomyopathyPatientsScintigraphy