2004
Involvement of Salmonella Pathogenicity Island 2 in the Up-Regulation of Interleukin-10 Expression in Macrophages: Role of Protein Kinase A Signal Pathway
Uchiya K, Groisman EA, Nikai T. Involvement of Salmonella Pathogenicity Island 2 in the Up-Regulation of Interleukin-10 Expression in Macrophages: Role of Protein Kinase A Signal Pathway. Infection And Immunity 2004, 72: 1964-1973. PMID: 15039316, PMCID: PMC375175, DOI: 10.1128/iai.72.4.1964-1973.2004.Peer-Reviewed Original ResearchConceptsSalmonella pathogenicity island 2Pathogenicity island 2Wild-type SalmonellaCyclic AMP response element binding proteinPKA activityProtein kinase A (PKA) signal pathwaySPI-2Island 2Signal transduction pathwaysProtein kinase A (PKA) inhibitor HResponse element-binding proteinA (PKA) inhibitor HElement-binding proteinFacultative intracellular bacteriaAMP response element binding proteinTransduction pathwaysSpiC genePKA activationSpiC mutantIntracellular bacteriaInhibitor HSignal pathwayCREB phosphorylationUp-RegulationPhosphorylation
1999
Pathogenicity Islands and the Evolution of Salmonella Virulence
Groisman E, Blanc‐Potard A, Uchiya K. Pathogenicity Islands and the Evolution of Salmonella Virulence. 1999, 127-150. DOI: 10.1128/9781555818173.ch7.Peer-Reviewed Original ResearchSPI-1 genesPathogenicity islandDNA segmentsSPI-1Evolution of SalmonellaCultured epithelial cellsSalmonella-specific sequenceTRNA genesExport apparatusTranscriptional unitsLarge operonNonhost environmentsSecretion systemBacterial entryHousekeeping genesSalmonella virulenceHost rangeSPI-2Secretory systemHost cellsAspects of infectionNonphagocytic cellsGenesMacrophage apoptosisOperon