2006
The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica
Tu X, Latifi T, Bougdour A, Gottesman S, Groisman EA. The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 13503-13508. PMID: 16938894, PMCID: PMC1557385, DOI: 10.1073/pnas.0606026103.Peer-Reviewed Original ResearchConceptsSigma factor RpoSPhoP/PhoQTwo-component systemAlternative sigma factor RpoSTwo-component regulatory system PhoP/PhoQPhoP/PhoQ.Stress response genesSalmonella enterica serovar TyphimuriumRpoS stabilityClpXP proteaseTranscriptional activatorEnterica serovar TyphimuriumRegulatory circuitsRpoS mutantResponse genesRegulatory proteinsProtein turnoverRpoSBacterial speciesEscherichia coliPhoP geneGenesSerovar TyphimuriumE. coliPhoQ
1992
Molecular genetic analysis of the Escherichia coli phoP locus
Groisman EA, Heffron F, Solomon F. Molecular genetic analysis of the Escherichia coli phoP locus. Journal Of Bacteriology 1992, 174: 486-491. PMID: 1530848, PMCID: PMC205741, DOI: 10.1128/jb.174.2.486-491.1992.Peer-Reviewed Original ResearchConceptsDeduced amino acid sequenceIsogenic wild-type strainE. coli genomePhoP geneMajor virulence regulatorAmino acid sequenceWild-type strainTwo-component systemMolecular genetic analysisColi genomePhoP locusVirulence regulatorIntramacrophage survivalAcid sequenceGenetic analysisEnteric speciesPhoP mutantE. coliGenesMagainin 2Cationic peptidesPhagocytic cellsGenomeHomologMutants
1989
Salmonella typhimurium phoP virulence gene is a transcriptional regulator.
Groisman EA, Chiao E, Lipps CJ, Heffron F. Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 7077-7081. PMID: 2674945, PMCID: PMC297997, DOI: 10.1073/pnas.86.18.7077.Peer-Reviewed Original ResearchConceptsExpression of lociAmino acid sequenceDifferent environmental stimuliFacultative intracellular pathogenGram-negative speciesTranscriptional regulatorsYeast SaccharomycesExtensive homologyDNA sequencesGene productsAcid sequenceHost phagocytic cellsPhosphate availabilityEnvironmental stimuliIntracellular pathogensPhoP genePhoP mutationVirulence genesPhoPGenesLociSequenceSalmonella typhimuriumPhagocytic cellsPhoB