2022
Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder
Smart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder. Alcohol Clinical And Experimental Research 2022, 46: 770-782. PMID: 35342968, PMCID: PMC9117461, DOI: 10.1111/acer.14816.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate 5 receptorsDefault mode networkFunctional magnetic resonance imagingReceptor availabilityPositron emission tomographyAUD groupFunctional connectivityReceptor positron emission tomographyResting-state functional magnetic resonance imagingNetwork-level functional connectivityBrain connectivityWeeks of abstinenceGlobal functional connectivityAlcohol use disorderMagnetic resonance imagingFMRI outcomesHealthy controlsSupervised abstinencePET resultsUse disordersSynaptic plasticityResonance imagingBrain regionsEmission tomographyOrbitofrontal cortex
2016
Fluctuations in Global Brain Activity Are Associated With Changes in Whole-Brain Connectivity of Functional Networks
Scheinost D, Tokoglu F, Shen X, Finn ES, Noble S, Papademetris X, Constable RT. Fluctuations in Global Brain Activity Are Associated With Changes in Whole-Brain Connectivity of Functional Networks. IEEE Transactions On Biomedical Engineering 2016, 63: 2540-2549. PMID: 27541328, PMCID: PMC5180443, DOI: 10.1109/tbme.2016.2600248.Peer-Reviewed Original ResearchConceptsGlobal brain activityResting-state networksWhole-brain connectivityBrain activityResting-state functional magnetic resonance imagingTime pointsFunctional resting-state networksFunctional magnetic resonance imagingMagnetic resonance imagingResting-state studyBrain statesRSN connectivitySensory functionSubcortical regionsResonance imagingCognitive functionCoactivation patternsUnique brain statesBrain connectivityActivity stateCritical time pointsFunctional networksSignal intensityVoxel-based methodBrain dynamicsPrenatal stress alters amygdala functional connectivity in preterm neonates
Scheinost D, Kwon SH, Lacadie C, Sze G, Sinha R, Constable RT, Ment LR. Prenatal stress alters amygdala functional connectivity in preterm neonates. NeuroImage Clinical 2016, 12: 381-388. PMID: 27622134, PMCID: PMC5009231, DOI: 10.1016/j.nicl.2016.08.010.Peer-Reviewed Original ResearchConceptsPrenatal stress exposurePreterm neonatesPreterm birthPrenatal stressStress exposureTerm controlsFunctional connectivityAmygdala connectivityNeuropsychiatric disordersResting-state functional magnetic resonance imagingPrenatal stress altersEarly life stressFunctional magnetic resonance imagingMagnetic resonance imagingPeristriate cortexPrenatal exposureHigh riskMaternal stressIndependent cohortNeonatesLeft amygdalaSubcortical regionsResonance imagingAmygdalaCohort
2014
The impact of image smoothness on intrinsic functional connectivity and head motion confounds
Scheinost D, Papademetris X, Constable RT. The impact of image smoothness on intrinsic functional connectivity and head motion confounds. NeuroImage 2014, 95: 13-21. PMID: 24657356, PMCID: PMC4076413, DOI: 10.1016/j.neuroimage.2014.03.035.Peer-Reviewed Original ResearchConceptsResting-state functional magnetic resonance imagingWhole-brain functional organizationFunctional magnetic resonance imagingIntrinsic functional connectivityMagnetic resonance imagingFunctional connectivity studiesResonance imagingRs-fMRIFunctional connectivityClinical populationsGroup differencesConnectivity studiesHead motionFunctional organizationHead movementsRecent studies