2009
Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events
Hoen AG, Margos G, Bent SJ, Diuk-Wasser MA, Barbour A, Kurtenbach K, Fish D. Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 15013-15018. PMID: 19706476, PMCID: PMC2727481, DOI: 10.1073/pnas.0903810106.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBacterial Typing TechniquesBase SequenceBorrelia burgdorferiDNA, BacterialLyme DiseasePhylogenyUnited StatesConceptsB. burgdorferi populationsPhylogeographic population structurePopulation size expansionBacterial housekeeping geneDisease emergence eventsPopulation structureRange expansionHousekeeping genesB. burgdorferiDescendent clonesEuropean settlementEmergence eventsEastern United StatesSize expansionCoastal ConnecticutTick vectorGeographic extent
2006
An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands
Sukumaran B, Narasimhan S, Anderson JF, DePonte K, Marcantonio N, Krishnan MN, Fish D, Telford SR, Kantor FS, Fikrig E. An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands. Journal Of Experimental Medicine 2006, 203: 1507-1517. PMID: 16717118, PMCID: PMC2118316, DOI: 10.1084/jem.20060208.Peer-Reviewed Original ResearchConceptsA. phagocytophilum-infected miceRNA interference-mediated silencingA. phagocytophilumTick salivary proteinsI. scapularis salivary glandsRickettsia-like pathogensTick salivary glandsMammalian hostsGenus RickettsiaAnaplasma phagocytophilumGene expressionSalivary glandsIntracellular organismsArthropodsSalivary proteinsPathogensProteinPhagocytophilumExpressionTicksHuman anaplasmosisSilencingGenesOrganismsAnaplasma
2004
Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe
Bunikis J, Garpmo U, Tsao J, Berglund J, Fish D, Barbour A. Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe. Microbiology 2004, 150: 1741-1755. PMID: 15184561, DOI: 10.1099/mic.0.26944-0.Peer-Reviewed Original ResearchConceptsIntergenic spacerGenetic diversityIGS locusIGS genotypesOspC allelesHigh nucleotide diversityDistinct clonal lineagesGreater genetic diversityB. burgdorferiNorth-eastern United StatesTick vector Ixodes scapularisNucleotide diversityMonophyletic lineageSignature nucleotidesPhylogenetic studiesLinkage groupsIGS sequencesPhylogenetic inferenceIntragenic recombinationExtensive strain diversityDetectable recombinationVector Ixodes scapularisClonal lineagesField sitesLoci
2000
Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A
Pal U, de Silva A, Montgomery R, Fish D, Anguita J, Anderson J, Lobet Y, Fikrig E. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. Journal Of Clinical Investigation 2000, 106: 561-569. PMID: 10953031, PMCID: PMC380253, DOI: 10.1172/jci9427.Peer-Reviewed Original Research