2021
Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis
Jain D, Sreenivasan P, Inayat I, Deng Y, Ciarleglio MM, Garcia-Tsao G. Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis. American Journal Of Clinical Pathology 2021, 156: 802-809. PMID: 33940622, PMCID: PMC8512277, DOI: 10.1093/ajcp/aqab024.Peer-Reviewed Original ResearchConceptsDevelopment of decompensationThick fibrous septaSeptal widthCompensated cirrhosisClinical decompensationSeptal thicknessFibrous septaEnd-stage liver disease (MELD) scorePrimary end pointSignificant portal hypertensionLiver Disease scoreLiver biopsy specimenLiver biopsy specimensNodule sizeCirrhosis decompensationHistologic cirrhosisCompensated patientsPortal hypertensionIndependent predictorsLiver biopsyCommon etiologyWorse prognosisBiopsy specimenBiopsy specimensUnivariate analysis
2012
Quantitative histological‐hemodynamic correlations in cirrhosis
Sethasine S, Jain D, Groszmann RJ, Garcia‐Tsao G. Quantitative histological‐hemodynamic correlations in cirrhosis. Hepatology 2012, 55: 1146-1153. PMID: 22109744, PMCID: PMC3721182, DOI: 10.1002/hep.24805.Peer-Reviewed Original ResearchConceptsSignificant portal hypertensionPortal hypertensionFibrosis areaLiver biopsyCirrhotic nodulesNodule sizeHVPG measurementPortal pressureIndependent predictorsSeptal thicknessFibrous septaBiopsyPathophysiological implicationsCirrhosisHVPGPatientsSemiquantitative analysisNodulesOnly parameterHypertensionNumber of nodules