Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 Patients
George S, Pal AC, Gagnon J, Timalsina S, Singh P, Vydyam P, Munshi M, Chiu JE, Renard I, Harden CA, Ott IM, Watkins AE, Vogels CBF, Lu P, Tokuyama M, Venkataraman A, Casanovas-Massana A, Wyllie AL, Rao V, Campbell M, Farhadian SF, Grubaugh ND, Dela Cruz CS, Ko AI, Perez A, Akaho EH, Moledina DG, Testani J, John AR, Ledizet M, Mamoun CB, Team A. Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 Patients. Kidney360 2021, 2: 924-936. PMID: 35373072, PMCID: PMC8791366, DOI: 10.34067/kid.0002172021.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 spike proteinSARS-CoV-2Spike proteinUrine samplesSARS-CoV-2 infectionYale-New Haven HospitalCOVID-19 patientsAntigen capture assayDetectable viral RNANew Haven HospitalPositive PCR resultsPossible long-term consequencesSpike S1 proteinNP PCRChildren's HospitalNasopharyngeal swabsSARS-CoV-2 spike S1 proteinRenal abnormalitiesLong-term effectsCystatin CLong-term consequencesHospitalUrineViral RNAAlbuminuriaPredicting patients with false negative SARS-CoV-2 testing at hospital admission: A retrospective multi-center study
Ghazi L, Simonov M, Mansour SG, Moledina DG, Greenberg JH, Yamamoto Y, Biswas A, Wilson FP. Predicting patients with false negative SARS-CoV-2 testing at hospital admission: A retrospective multi-center study. PLOS ONE 2021, 16: e0251376. PMID: 33979353, PMCID: PMC8115794, DOI: 10.1371/journal.pone.0251376.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionHours of hospitalizationReceiver operator characteristicAdult patientsNegative SARS-CoV-2 testYale New Haven Health SystemLower white blood cell countAvailable electronic health record dataRetrospective multi-center studySARS-CoV-2 positivityWhite blood cell countSARS-CoV-2 testSARS-CoV-2 testingPositive COVID testHospitalized adult patientsRetrospective cohort studyPopulation of patientsElectronic health record dataBlood cell countVital sign abnormalitiesMulti-center studyFalse-negative testingHealth record dataSARS-CoV-2 virusSARS-CoV-2