2019
Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice
Bagdas D, Diester C, Riley J, Carper M, Alkhlaif Y, AlOmari D, Alayoubi H, Poklis J, Damaj M. Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice. Neuropharmacology 2019, 157: 107669. PMID: 31220484, PMCID: PMC6697382, DOI: 10.1016/j.neuropharm.2019.107669.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AddictiveChoice BehaviorDose-Response Relationship, DrugDrug InteractionsFemaleMaleMiceMice, KnockoutNicotineNucleus AccumbensQuinineReceptors, NicotinicSelf AdministrationSex CharacteristicsSubstance Withdrawal SyndromeTobacco Use DisorderTyrosine 3-MonooxygenaseVareniclineConceptsAddictive-like propertiesNicotine intakeOral nicotine consumptionNicotine consumptionFree-choice paradigmNicotine solutionΑ6 KO miceTwo-bottle free-choice paradigmTyrosine hydroxylase levelsNicotinic acetylcholine receptor subunitsPartial agonist vareniclineOral nicotine intakeAbsence of nicotineAcetylcholine receptor subunitsΑ5 nAChRAdult C57BL/6JNicotine withdrawalKO miceFemale miceAgonist vareniclineDBA/2J miceHydroxylase levelsNicotine dependenceBinge drinkingObserved sex differences
2017
In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence
Jackson A, Bagdas D, Muldoon PP, Lichtman AH, Carroll FI, Greenwald M, Miles MF, Damaj MI. In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence. Neuropharmacology 2017, 118: 38-45. PMID: 28279662, PMCID: PMC5410388, DOI: 10.1016/j.neuropharm.2017.03.005.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAnesthetics, LocalAnimalsBenzamidesBridged Bicyclo CompoundsCocaineConditioning, OperantDisease Models, AnimalFenofibrateHypolipidemic AgentsMaleMiceMice, Inbred ICRNicotineNicotinic AgonistsOxazolesPPAR alphaPyrimidinesSelf AdministrationSubstance Withdrawal SyndromeTobacco Use DisorderTyrosineConceptsNicotine dependenceNicotinic acetylcholine receptorsNicotine rewardΑ7 nAChRsNicotine CPPWY-14643Acetylcholine receptorsRewarding propertiesNuclear peroxisome proliferator-activated receptorsΑ7 nicotinic acetylcholine receptorVentral tegmental area dopamine cellsEffect of α7Peroxisome proliferator-activated receptorNicotine withdrawal signsSmoking cessation therapyChronic tobacco useCurrent smoking cessation therapiesPPARα antagonist GW6471Main addictive componentPPARα-dependent mannerProliferator-activated receptorNicotine rewarding propertiesPlace preference testHomomeric α7 nAChRsSelf-administration model