2023
A systematic review and individual participant data meta-analysis of gonadal steroid hormone receptors in meningioma.
Miyagishima D, Sundaresan V, Gutierrez A, Barak T, Yeung J, Moliterno J, McGuone D, Claus E, Günel M. A systematic review and individual participant data meta-analysis of gonadal steroid hormone receptors in meningioma. Journal Of Neurosurgery 2023, 139: 1638-1647. PMID: 37243565, PMCID: PMC10226381, DOI: 10.3171/2023.3.jns221838.Peer-Reviewed Original ResearchMeSH KeywordsFemaleGonadal Steroid HormonesHumansImmunohistochemistryMaleMeningeal NeoplasmsMeningiomaReceptors, EstrogenSkull BaseConceptsIndividual participant dataHR statusProgesterone receptorAndrogen receptorEstrogen receptorHormone receptorsFemale patientsParticipant dataSystematic reviewGonadal steroid hormone receptorsRisk of biasGonadal steroid hormonesPubMed literature reviewProper patient stratificationSkull base locationSteroid hormone receptorsHormonal therapyER expressionUnduplicated articlesFemale sexGrade IIndependent associationPatient stratificationConvexity locationStudy heterogeneity
2017
Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis
Lam JD, Oh DJ, Wong LL, Amarnani D, Park-Windhol C, Sanchez AV, Cardona-Velez J, McGuone D, Stemmer-Rachamimov AO, Eliott D, Bielenberg DR, van Zyl T, Shen L, Gai X, D'Amore PA, Kim LA, Arboleda-Velasquez JF. Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis. Diabetes 2017, 66: db161035. PMID: 28400392, PMCID: PMC5482092, DOI: 10.2337/db16-1035.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnimalsCell MovementCell ProliferationCore Binding Factor Alpha 2 SubunitDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic RetinopathyDisease Models, AnimalEndothelial CellsFemaleGlucoseHumansImmunohistochemistryMaleMiceMiddle AgedOxygenRetinaRetinal NeovascularizationRNA, MessengerConceptsAberrant retinal angiogenesisHuman retinal microvascular endothelial cellsProliferative diabetic retinopathyOxygen-induced retinopathyFibrovascular membranesRetinal angiogenesisEndothelial cellsRetinal microvascular endothelial cellsType 2 diabetesRetina of miceMicrovascular endothelial cellsVascular endothelial cellsNeovascular tuftsDiabetic retinopathyTranscription factor 1Common causeRUNX1 inhibitionImmunohistochemical stainingAdult populationHigh glucoseType 1RetinopathyProtein expressionTube formationFactor 1Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease
Williams EA, McGuone D, Frosch MP, Hyman BT, Laver N, Stemmer-Rachamimov A. Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease. Journal Of Neuropathology & Experimental Neurology 2017, 76: 376-383. PMID: 28379416, PMCID: PMC7191616, DOI: 10.1093/jnen/nlx020.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseMacular degenerationΒ-amyloidAlzheimer's disease neuropathologic changeAD-related changesAge-matched controlsEyes of subjectsAD-related featuresSeverity of changesAlzheimer changesNeuropathologic changesPathologic findingsAutopsy casesVisual deficitsCommon causeTDP-43Pathology studiesTau proteinExtracellular depositionΑ-synucleinIntracellular accumulationBrainSimilar changesDegenerationDisease
2015
Characterization of cells from patient-derived fibrovascular membranes in proliferative diabetic retinopathy.
Kim LA, Wong LL, Amarnani DS, Bigger-Allen AA, Hu Y, Marko CK, Eliott D, Shah VA, McGuone D, Stemmer-Rachamimov AO, Gai X, D'Amore PA, Arboleda-Velasquez JF. Characterization of cells from patient-derived fibrovascular membranes in proliferative diabetic retinopathy. Molecular Vision 2015, 21: 673-87. PMID: 26120272, PMCID: PMC4462955.Peer-Reviewed Original ResearchConceptsComparative genomic hybridizationDiscovery of cellsPlasma membrane infoldingsSpecific cell populationsCell identityPrimary culturesCell culture modelCharacterization of cellsMajor chromosomal aberrationsMembrane infoldingsCellular constituentsGenomic hybridizationAlpha-smooth muscle actinThrombospondin-1Cell populationsExpression of markersCulture conditionsStromal cellsPerivascular cellsCulture modelUnique resourceGlial fibrillary acidic protein-positive cellsCellsChromosomal aberrationsEndothelial cellsFailure to detect human papillomavirus in focal cortical dysplasia type IIb
Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-Rachamimov A, Staley KJ. Failure to detect human papillomavirus in focal cortical dysplasia type IIb. Annals Of Neurology 2015, 78: 63-67. PMID: 25893423, DOI: 10.1002/ana.24422.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasia type IIbFocal cortical dysplasiaHPV infectionCortical dysplasiaSurgical centersAbsence of HPVType IIBSingle surgical centerHuman papillomavirus 16Situ hybridizationHPV 16Human papillomavirusPolymerase chain reactionSurgical specimensDNA polymerase chain reactionIndependent cohortViral infectionFetal developmentPathological specimensInfectionCausative agentChain reactionCausal roleHPVDysplasia