2021
A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model
Costine-Bartell B, Price G, Shen J, McGuone D, Staley K, Duhaime AC. A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model. Neurobiology Of Disease 2021, 154: 105334. PMID: 33753291, PMCID: PMC8135256, DOI: 10.1016/j.nbd.2021.105334.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injurySeizure durationHemispheric hypodensitySubarachnoid hemorrhageTissue damageSevere typeTraumatic brain injury modelSevere traumatic brain injuryEffects of seizuresSevere brain injuryFocal subarachnoid hemorrhageBrain injury modelHuman infantsPotential therapeutic targetLarge animal modelGray matter regionsPattern of damageMultifactorial injuryNeurologic scoresCortical impactSham injurySeizure inductionIntensive careSubdural hematomaSeizure‐related deaths in children: The expanding spectrum
Harowitz J, Crandall L, McGuone D, Devinsky O. Seizure‐related deaths in children: The expanding spectrum. Epilepsia 2021, 62: 570-582. PMID: 33586153, PMCID: PMC7986159, DOI: 10.1111/epi.16833.Peer-Reviewed Original ResearchConceptsSeizure-related deathSudden unexpected infant deathSudden unexplained deathUnexpected infant deathEpileptic factorsMale predominanceNonfebrile seizuresHippocampal abnormalitiesFetal lossProne positionUnexplained deathUnexpected deathFamily historyNeuronal excitabilityInfant deathUnwitnessed deathsEpidemiological studiesEpilepsy shareEpilepsy diagnosisDeathGenetic featuresSeizuresChildrenPotential causesFebrile
2015
The Subventricular Zone in the Immature Piglet Brain: Anatomy and Exodus of Neuroblasts into White Matter after Traumatic Brain Injury
Costine BA, Missios S, Taylor SR, McGuone D, Smith CM, Dodge CP, Harris BT, Duhaime AC. The Subventricular Zone in the Immature Piglet Brain: Anatomy and Exodus of Neuroblasts into White Matter after Traumatic Brain Injury. Developmental Neuroscience 2015, 37: 115-130. PMID: 25678047, PMCID: PMC4406780, DOI: 10.1159/000369091.Peer-Reviewed Original ResearchConceptsTraumatic brain injurySubventricular zoneWhite matterWhite matter tractsNumber of neuroblastsPostnatal neurogenesisBrain injuryEffects of TBICortical impact modelPostnatal day 14Human infantsGyral white matterNeurogenic precursor cellsYounger age groupsMonths of ageSVZ areaPND 7Contralateral hemisphereGyrencephalic brainGyrencephalic speciesPiglet brainLesion siteLarge lesionsLesion sizeDay 14