2021
A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model
Costine-Bartell B, Price G, Shen J, McGuone D, Staley K, Duhaime AC. A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model. Neurobiology Of Disease 2021, 154: 105334. PMID: 33753291, PMCID: PMC8135256, DOI: 10.1016/j.nbd.2021.105334.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injurySeizure durationHemispheric hypodensitySubarachnoid hemorrhageTissue damageSevere typeTraumatic brain injury modelSevere traumatic brain injuryEffects of seizuresSevere brain injuryFocal subarachnoid hemorrhageBrain injury modelHuman infantsPotential therapeutic targetLarge animal modelGray matter regionsPattern of damageMultifactorial injuryNeurologic scoresCortical impactSham injurySeizure inductionIntensive careSubdural hematoma
2016
Neuroblast Distribution after Cortical Impact Is Influenced by White Matter Injury in the Immature Gyrencephalic Brain
Taylor SR, Smith CM, Keeley KL, McGuone D, Dodge CP, Duhaime AC, Costine BA. Neuroblast Distribution after Cortical Impact Is Influenced by White Matter Injury in the Immature Gyrencephalic Brain. Frontiers In Neuroscience 2016, 10: 387. PMID: 27601978, PMCID: PMC4994423, DOI: 10.3389/fnins.2016.00387.Peer-Reviewed Original ResearchTraumatic brain injuryWhite matter injuryCortical impactSubventricular zoneWhite matterGyrencephalic brainBrain regionsInjury sitePostnatal populationGray matterPostnatal day 7Age-dependent increaseNumber of neuroblastsCortical contusionNeurogenic responseCortical injuryMajor white matterSham surgeryPND 14PND 5Potential complicationsBrain injuryPopulation of neuroblastsDay 7Chronic effects