2020
Neuropathologic Changes in Sudden Unexplained Death in Childhood
McGuone D, Leitner D, William C, Faustin A, Leelatian N, Reichard R, Shepherd TM, Snuderl M, Crandall L, Wisniewski T, Devinsky O. Neuropathologic Changes in Sudden Unexplained Death in Childhood. Journal Of Neuropathology & Experimental Neurology 2020, 79: 336-346. PMID: 31995186, PMCID: PMC7036658, DOI: 10.1093/jnen/nlz136.Peer-Reviewed Original ResearchConceptsSudden unexplained deathHippocampal abnormalitiesUnexplained deathHippocampal findingsNumber of seizuresBoard-certified neuropathologistsCause of deathComprehensive case investigationMultiple chromosomal aberrationsSeizure pathogenesisSUDC casesFebrile seizuresHippocampal alterationsMedian ageHistological reviewNeuropathologic changesNeuropathologic investigationDentate gyrusProne positionCommon findingAncillary testingAutopsy dataMolecular testingApparent sleepBrain samples
2018
Development of a Model of Hemispheric Hypodensity (“Big Black Brain”)
Costine-Bartell B, McGuone D, Price G, Crawford E, Keeley K, Munoz-Pareja J, Dodge CP, Staley K, Duhaime AC. Development of a Model of Hemispheric Hypodensity (“Big Black Brain”). Journal Of Neurotrauma 2018, 36: 815-833. PMID: 30039743, PMCID: PMC6387571, DOI: 10.1089/neu.2018.5736.Peer-Reviewed Original ResearchConceptsHemispheric hypodensitySubdural hematomaAbusive head traumaMultiple vascular territoriesMechanism of traumaSevere brain damagePatterns of injuryDeep gray matterSeizure durationHead traumaMultiple injuriesPathological examinationKainic acidSevere seizuresVasogenic edemaBrain damageContralateral sideVascular territoriesCommon findingMetabolic mismatchRelative sparingAnimal modelsRadiological indicatorsCortical ribbonGray matter