2015
Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing
Kunstman JW, Juhlin CC, Goh G, Brown TC, Stenman A, Healy JM, Rubinstein JC, Choi M, Kiss N, Nelson-Williams C, Mane S, Rimm DL, Prasad ML, Höög A, Zedenius J, Larsson C, Korah R, Lifton RP, Carling T. Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing. Human Molecular Genetics 2015, 24: 2318-2329. PMID: 25576899, PMCID: PMC4380073, DOI: 10.1093/hmg/ddu749.Peer-Reviewed Original Research
2012
Spatial spectral imaging as an adjunct to the Bethesda classification of thyroid fine‐needle aspiration specimens
Hahn LD, Hoyt C, Rimm DL, Theoharis C. Spatial spectral imaging as an adjunct to the Bethesda classification of thyroid fine‐needle aspiration specimens. Cancer Cytopathology 2012, 121: 162-167. PMID: 22833451, DOI: 10.1002/cncy.21224.Peer-Reviewed Original Research
2007
Fine‐needle aspiration of follicular adenoma versus parathyroid adenoma
Mansoor I, Zalles C, Zahid F, Gossage K, Levenson RM, Rimm DL. Fine‐needle aspiration of follicular adenoma versus parathyroid adenoma. Cancer 2007, 114: 22-26. PMID: 18085636, DOI: 10.1002/cncr.23252.Peer-Reviewed Original ResearchConceptsArtificial intelligence systemsSpatial-spectral featuresSpectral image informationMultispectral image analysisIntelligence systemsImage informationAlgorithmic solutionTraining setImage stacksImaging solutionImage analysisTest casesHuman eyeImagesClassifierSoftwareToolPlatformSolutionTechnologyInformationSet
2006
The value of onsite adequacy assessment of thyroid fine‐needle aspirations is a function of operator experience
Ghofrani M, Beckman D, Rimm DL. The value of onsite adequacy assessment of thyroid fine‐needle aspirations is a function of operator experience. Cancer 2006, 108: 110-113. PMID: 16400635, DOI: 10.1002/cncr.21715.Peer-Reviewed Original ResearchMeSH KeywordsBiopsy, Fine-NeedleFemaleHumansMaleMiddle AgedSpecimen HandlingThyroid DiseasesThyroid GlandThyroid NeoplasmsUltrasonographyConceptsFine-needle aspirationThyroid fine-needle aspirationPalpation-guided fine-needle aspirationNondiagnostic rateOnsite evaluationUS guidancePerformance of FNAImmediate adequacy assessmentCurrent studyLower nondiagnostic rateFinal diagnosisChi-square analysisCytologic diagnosisNondiagnostic specimensNondiagnostic aspiratesPalpationSignificant decreaseDiagnosisImmediate evaluationExperienced radiologistsRadiologistsOperator experienceExperienced operatorsAdequate materialLess experience
2001
β-Catenin Dysregulation in Thyroid Neoplasms Down-Regulation, Aberrant Nuclear Expression, and CTNNB1 Exon 3 Mutations Are Markers for Aggressive Tumor Phenotypes and Poor Prognosis
Garcia-Rostan G, Camp R, Herrero A, Carcangiu M, Rimm D, Tallini G. β-Catenin Dysregulation in Thyroid Neoplasms Down-Regulation, Aberrant Nuclear Expression, and CTNNB1 Exon 3 Mutations Are Markers for Aggressive Tumor Phenotypes and Poor Prognosis. American Journal Of Pathology 2001, 158: 987-996. PMID: 11238046, PMCID: PMC1850336, DOI: 10.1016/s0002-9440(10)64045-x.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAdultAgedBeta CateninBiomarkers, TumorCarcinomaCell DivisionCell NucleusCytoskeletal ProteinsDown-RegulationExonsFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedOncogene Protein p21(ras)PhenotypePoint MutationPolymorphism, Single-Stranded ConformationalPrognosisSurvival RateThyroid NeoplasmsTrans-ActivatorsConceptsPoor prognosisTumor differentiationBeta-catenin expressionConventional prognostic indicatorsAggressive tumor phenotypeNuclear beta-catenin localizationThyroid tumor samplesBeta-catenin dysregulationAberrant nuclear expressionΒ-catenin dysregulationDifferentiated tumorsPrognostic indicatorThyroid cancerThyroid neoplasmsNuclear immunoreactivityBeta-catenin alterationsNuclear expressionTumor samplesProgressive lossCarcinomaTumor phenotypeSingle-strand conformational polymorphismBeta-catenin mutationsHuman cancersDown regulation
1999
Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma.
Garcia-Rostan G, Tallini G, Herrero A, D'Aquila TG, Carcangiu ML, Rimm DL. Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma. Cancer Research 1999, 59: 1811-5. PMID: 10213482.Peer-Reviewed Original ResearchConceptsNuclear localizationSingle-strand conformational polymorphismE-cadherin-mediated cell-cell adhesionBeta-catenin actsFrequent nuclear localizationCell-cell adhesionExon 3Conformational polymorphismBeta-catenin genePhosphorylation sitesWingless pathwayTranscriptional activationCytoplasmic proteinsSubcellular localizationMobility shiftMutational analysisNucleotide sequencingDNA sequencingNuclear translocationSomatic alterationsMutationsAnaplastic thyroid carcinomaSequencingProteinFrequent mutations
1997
Comparison of the costs of fine‐needle aspiration and open surgical biopsy as methods for obtaining a pathologic diagnosis
Rimm D, Stastny J, Rimm E, Ayer S, Frable W. Comparison of the costs of fine‐needle aspiration and open surgical biopsy as methods for obtaining a pathologic diagnosis. Cancer 1997, 81: 51-56. PMID: 9100542, DOI: 10.1002/(sici)1097-0142(19970225)81:1<51::aid-cncr11>3.0.co;2-b.Peer-Reviewed Original Research