2018
Cutaneous immunohistochemical staining pattern of p53β isoforms
Ko CJ, Myung P, Leffell DJ, Bourdon JC. Cutaneous immunohistochemical staining pattern of p53β isoforms. Journal Of Clinical Pathology 2018, 71: 1120. PMID: 30305316, DOI: 10.1136/jclinpath-2018-205098.Peer-Reviewed Original ResearchConceptsSquamous tumorsMarkers of differentiationSquamous proliferationIsoforms of p53Mutational statusHair folliclesP53 pathwayDomain mutationsExact biological significanceP53Differentiated layersSkinP53 isoformsSuch mutationsIsoformsDifferent isoformsNumerous functionsTumorsCancerMutationsFolliclesBiological significance
2017
Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases
Ko CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases. Journal Of The American Academy Of Dermatology 2017, 77: 1126-1132.e1. PMID: 28709693, DOI: 10.1016/j.jaad.2017.04.1119.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaProminent cytologic atypiaMultiple squamous cell carcinomasCytologic atypiaSquamous proliferationTP53 mutationsDetectable TP53 mutationsLegs of womenFollicle-like structuresCell carcinomaHistopathologic findingsMultiple lesionsSCC lesionsHistopathologic analysisTP53 sequencingNumerous tumorsSmall seriesTP53 variantsClinical phenotypeKeratoacanthomaLesionsTumorsDifferent patientsAtypiaReactive phenomenonWell‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63
Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well‐differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. Journal Of Cutaneous Pathology 2017, 44: 557-562. PMID: 28417484, DOI: 10.1111/cup.12952.Peer-Reviewed Original ResearchConceptsCutaneous adnexal neoplasmsAdnexal neoplasmsNeuroendocrine tumorsAdnexal tumorsBenign skin adnexal tumorCutaneous adnexal tumorsAggressive metastatic diseaseLow-grade tumorsSkin adnexal tumorsMajority of casesMetastatic diseaseMetastatic adenocarcinomaCarcinoid tumorsCytokeratin 5/6Diagnostic challengeDifferential diagnosisImmunohistochemical stainsCK5/6Diagnostic utilityPrimary siteTumorsNeoplasmsFirst signWDNETsP63
2016
Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity
Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-765. PMID: 27220356, DOI: 10.1111/cup.12738.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMultiple squamous cell carcinomasCutaneous squamous cell carcinomaHistopathologic featuresCell carcinomaLower extremitiesMultiple cutaneous squamous cell carcinomasRetrospective chart reviewAmerican Joint CommitteeCancer staging criteriaDistinct clinical subtypesChart reviewPerineural invasionActinic keratosisStaging criteriaClinical subtypesMost lesionsStage IJoint CommitteeStage IIKeratoacanthomaPatientsCarcinomaTumorsSubtypes
2015
Melanoma in situ Part II. Histopathology, treatment, and clinical management
Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ Part II. Histopathology, treatment, and clinical management. Journal Of The American Academy Of Dermatology 2015, 73: 193-203. PMID: 26183968, DOI: 10.1016/j.jaad.2015.03.057.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAminoquinolinesBiopsy, NeedleCarcinoma in SituFemaleHumansImiquimodImmunohistochemistryImmunotherapyInjections, IntralesionalInterferon-alphaLaser TherapyMaleMelanomaMohs SurgeryNeoplasm InvasivenessNeoplasm StagingPrognosisRandomized Controlled Trials as TopicSkin NeoplasmsTreatment Outcome
2010
Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature
Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature. American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/dad.0b013e3181b623c4.Peer-Reviewed Case Reports and Technical NotesConceptsDuctal carcinomaShave biopsyEccrine ductal carcinomaInitial shave biopsySuperficial shave biopsiesMohs micrographic surgeryRare adnexal tumorTreatment guidelinesCase reportDiagnostic challengeMicrographic surgeryBiologic behaviorComplete excisionAdnexal tumorsImmunohistochemical approachBiopsyCarcinomaRare variantsTumorsDiagnostic purposesPatientsSurgeryNeoplasmsExcisionCancer
2009
Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining
Ko CJ, Leffell DJ, McNiff JM. Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining. Journal Of Cutaneous Pathology 2009, 36: 448-452. PMID: 19278431, DOI: 10.1111/j.1600-0560.2008.01083.x.Peer-Reviewed Original ResearchConceptsCytokeratin 5/6Adenosquamous carcinomaPrimary cutaneous originSubset of casesCutaneous originMetastatic adenocarcinomaAppropriate therapyRare tumorGlandular differentiationCytokeratin 7Such tumorsDiffuse positivityLuminal areaTumorsCarcinomaAggressive behaviorP63StainClose associationAdenocarcinomaTherapyLesionsCasesPositivity
2007
Management of nonmelanoma skin cancer in 2007
Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in 2007. Nature Reviews Clinical Oncology 2007, 4: 462-469. PMID: 17657251, DOI: 10.1038/ncponc0883.Peer-Reviewed Original ResearchConceptsNonmelanoma skin cancerSkin cancerNew noninvasive treatmentImmune response modifiersMohs micrographic surgeryTopical chemotherapeuticsSelect tumorsHistological patternMicrographic surgerySurgical methodsConventional excisionNoninvasive optionNoninvasive treatmentTumor typesSurgeryCancerPhotodynamic therapyTreatmentCurettageMorbidityElectrodesiccationTherapyTumorsExcisionRetinoids
2005
Mohs micrographic surgery: established uses and emerging trends.
Pennington BE, Leffell DJ. Mohs micrographic surgery: established uses and emerging trends. Oncology 2005, 19: 1165-71; discussion 1171-2, 1175. PMID: 16255133.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaBasal cell carcinomaMohs micrographic surgeryCell carcinomaMicrographic surgeryCommon cutaneous neoplasmsConventional surgical excisionExtramammary Paget's diseaseMicrocystic adnexal carcinomaMerkel cell carcinomaCutaneous neoplasmsPaget's diseaseResidual tumorSurgical excisionAdnexal carcinomaCommon cancerCutaneous tumorsSurgical techniqueDermatofibrosarcoma protuberansCarcinomaDeep marginTissue conservationSurgeryTumorsDisease
2001
Common Benign and Malignant Skin Lesions
Asgari M, Leffell D. Common Benign and Malignant Skin Lesions. 2001, 867-884. DOI: 10.1007/978-1-4757-3432-4_61.Peer-Reviewed Original Research
1999
Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery.
McGovern T, Grossman D, Fitzgerald D, Glusac E, Leffell D. Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery. JAMA Dermatology 1999, 135: 1557-9. PMID: 10606080, DOI: 10.1001/archderm.135.12.1557.Peer-Reviewed Original Research
1993
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4216-4220. PMID: 8483937, PMCID: PMC46477, DOI: 10.1073/pnas.90.9.4216.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaCell carcinomaSkin cancerPercent of tumorsSquamous cell carcinomaNonmelanoma skin cancerP53 tumor suppressor geneDipyrimidine sitesBCC developmentMutation hotspotsCancerTumor suppressor geneP53 genePoint mutationsAllelic lossCarcinomaTwo-thirdsSuppressor geneGenetic eventsSkinP53Such mutationsMutationsCarcinogenic mutationsTumors
1992
Lasers in Dermatology and Ophthalmology
Leffell D, Thompson J. Lasers in Dermatology and Ophthalmology. Dermatologic Clinics 1992, 10: 687-700. PMID: 1395152, DOI: 10.1016/s0733-8635(18)30305-x.Peer-Reviewed Original ResearchConceptsVascular retinal diseasesOpen-angle glaucomaSpecific disease processesPort-wine stainsMacular edemaClosure glaucomaAngle glaucomaIntraocular tumorsNeoplastic lesionsAdnexal tumorsDisease processRetinal diseasesLaser treatmentDermatologyWine stainsGlaucomaOphthalmologyTumorsTreatmentUse of lasersDevelopmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9
Gailani M, Bale S, Leffell D, DiGiovanna J, Peck G, Poliak S, Drum M, Pastakia B, McBride O, Kase R, Greene M, Mulvihill J, Bale A. Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. Cell 1992, 69: 111-117. PMID: 1348213, DOI: 10.1016/0092-8674(92)90122-s.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaSporadic basal cell carcinomasCell carcinomaLoss of heterozygosityGorlin syndromeHereditary tumorsTumor suppressor geneHereditary basal cell carcinomasMultiple congenital anomaliesSuppressor geneAutosomal dominant disorderOvarian fibromaCongenital anomaliesCarcinomaGermline mutationsHereditary disorderPutative tumor suppressor geneDevelopmental defectsSyndromeGorlin syndrome geneDominant disorderAllelic lossGenetic linkage studiesTumorsTumor suppressor