2017
Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment
Lucca LE, Hafler DA. Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. Journal Of Clinical Investigation 2017, 127: 1218-1220. PMID: 28319049, PMCID: PMC5373854, DOI: 10.1172/jci93565.Peer-Reviewed Original ResearchConceptsT cellsRecruitment of CD8Antitumor immune responseT cell recruitmentMigration of CD8Cell lung tumorsSyngeneic gliomaChemokines CXCL9Tumor escapeTumor controlImmune infiltrationMetastatic melanomaClinical trialsMalignant gliomasExpression of STAT1Immune surveillanceLung tumorsImmune responseAggressive cancerCell recruitmentCD8Tumor destructionTumorsGliomasCommon mutations
1988
Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody.
Borst J, van Dongen JJ, Bolhuis RL, Peters PJ, Hafler DA, de Vries E, van de Griend RJ. Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody. Journal Of Experimental Medicine 1988, 167: 1625-1644. PMID: 2966845, PMCID: PMC2188932, DOI: 10.1084/jem.167.5.1625.Peer-Reviewed Original ResearchConceptsTCR gamma/deltaT lymphocytesPeripheral bloodHuman TCR-gamma/deltaT cell receptor gamma/deltaGrowth factorGamma/deltaViable T cellsT cell clonesDistinct immune functionsTarget cell recognitionDifferent receptor typesHuman T lymphocytesCD8 antigenDelta antibodyIL-2Murine T lymphocytesT cellsCell surface iodinationCytolytic activityImmune functionReceptor typesLymphocytesTCR moleculesNormal individuals