Abnormal Tr1 differentiation in multiple sclerosis
Astier AL, Hafler DA. Abnormal Tr1 differentiation in multiple sclerosis. Journal Of Neuroimmunology 2007, 191: 70-78. PMID: 17936368, PMCID: PMC2200628, DOI: 10.1016/j.jneuroim.2007.09.018.Peer-Reviewed Original ResearchConceptsMultiple sclerosisCentral nervous systemRegulatory T cell defectsInduction of TregsInflammatory demyelinating diseaseIL-10 secretionRegulatory T cellsHuman autoimmune diseasesT cell defectsContext of autoimmunityHigh TregTr1 differentiationTreg activityDemyelinating diseaseTreg cellsImmunosuppressive roleAutoimmune diseasesT cellsNervous systemAltered functionCell defectsSuch diseasesDiseaseTregsSclerosis