2022
Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis
Asashima H, Axisa PP, Pham THG, Longbrake EE, Ruff WE, Lele N, Cohen I, Raddassi K, Sumida TS, Hafler DA. Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis. Journal Of Clinical Investigation 2022, 132: e156254. PMID: 36250467, PMCID: PMC9566906, DOI: 10.1172/jci156254.Peer-Reviewed Original ResearchConceptsRelapsing-remitting multiple sclerosisMemory B cellsCTfh cellsB cellsTIGIT expressionMultiple sclerosisT cellsFollicular helper T cellsHealthy age-matched controlsB-cell depletionT cell expansionHelper T cellsAge-matched controlsB cell functionB-cell pathwayDifferential gene expression signaturesTfh cellsDisease activityGene expression signaturesCell depletionCD40 ligandTranscription factor TCF4Disease pathogenesisImmune systemNew MRI
2012
High salt induces pathogenic Th17 cells and exacerbates autoimmune diseases (60.13)
Kleinewietfeld M, Manzel A, Wu C, Titze J, Kuchroo V, Linker R, Muller D, Hafler D. High salt induces pathogenic Th17 cells and exacerbates autoimmune diseases (60.13). The Journal Of Immunology 2012, 188: 60.13-60.13. DOI: 10.4049/jimmunol.188.supp.60.13.Peer-Reviewed Original ResearchPathogenic Th17 cellsExperimental autoimmune encephalomyelitisEnvironmental risk factorsTh17 cellsAutoimmune diseasesRisk factorsMultiple sclerosisHigh-salt dietHelper T cellsGenetic risk factorsExacerbated inductionAutoimmune encephalomyelitisSalt dietSalt intakeCardiovascular diseaseT cellsSun exposureSevere formDiseaseGenetic factorsDietCertain pathogensInduction of murineInductionPivotal role