1997
Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands.
Dressel A, Chin JL, Sette A, Gausling R, Höllsberg P, Hafler DA. Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands. The Journal Of Immunology 1997, 159: 4943-51. PMID: 9366420, DOI: 10.4049/jimmunol.159.10.4943.Peer-Reviewed Original ResearchConceptsT cell clonesCD8 T cell clonesTCR contact residuesHLA-A2Superagonist peptideCell clonesSelf-AgHLA-A2.1 binding motifsHuman autoimmune diseasesAltered peptide ligandMHC class IMyelin peptidesHLA-A2.1Autoimmune diseasesAutoantigen recognitionSecrete cytokinesEffector responsesLow MHCImmune responseAgonist responsesImmunodominant epitopesAgonist peptideAg recognitionContact residuesCytotoxic response
1996
Induction of anergy in CD8 T cells by B cell presentation of antigen.
Höllsberg P, Batra V, Dressel A, Hafler DA. Induction of anergy in CD8 T cells by B cell presentation of antigen. The Journal Of Immunology 1996, 157: 5269-76. PMID: 8955172, DOI: 10.4049/jimmunol.157.12.5269.Peer-Reviewed Original ResearchMeSH KeywordsAntigen-Presenting CellsB-LymphocytesB7-1 AntigenCD40 LigandCD8-Positive T-LymphocytesCell LineClonal AnergyCytotoxicity, ImmunologicGene ExpressionHumansImmunologic MemoryInterleukin-2Lymphocyte ActivationMembrane GlycoproteinsReceptors, Antigen, T-CellSignal TransductionTranscription, GeneticConceptsCD8 T cellsT cell clonesInduction of anergyT cellsB cellsMononuclear cellsB7-1Cell clonesAg stimulationAnergic CD8 T cellsPeptide-pulsed B cellsPeptide-pulsed target cellsCD4 T-cell clonesCD8 T cell clonesSecondary Ag challengeExogenous IL-2B7-2 costimulationB cell presentationT cell anergyIL-2 secretionNormal proliferative responseIL-2 mRNA transcriptionT cell stimulationEarly tyrosine phosphorylationAdequate costimulation
1995
Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand.
Höllsberg P, Weber WE, Dangond F, Batra V, Sette A, Hafler DA. Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 4036-4040. PMID: 7732026, PMCID: PMC42097, DOI: 10.1073/pnas.92.9.4036.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceB-LymphocytesBinding SitesCD8-Positive T-LymphocytesCell DivisionCell Line, TransformedCytotoxicity, ImmunologicGene Products, taxHerpesvirus 4, HumanHLA-A2 AntigenHuman T-lymphotropic virus 1HumansKineticsLymphocyte ActivationMolecular Sequence DataMutagenesis, Site-DirectedPoint MutationThymidineConceptsCD8 T cellsInterleukin-2 secretionT cell receptor contact residuesT cellsReceptor contact residuesCD8 T cell clonesCytotoxic CD8 T cellsMyelopathy/tropical spastic paraparesisT cell-mediated cytotoxicityHAM/TSPTropical spastic paraparesisT cell clonesAltered peptide ligandT cell-mediated cytolysisHuman T-cell leukemia virus type IT cell stimulationVirus type IAnalog peptidesHLA-A2Spastic paraparesisNeurologic diseaseSecondary stimulationSecondary responsePeptide antigensPrimary activation