1991
Common T‐cell receptor Vβ usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis
Lee S, Wucherpfennig K, Brod S, Benjamin D, Weiner H, Hafler D. Common T‐cell receptor Vβ usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Annals Of Neurology 1991, 29: 33-40. PMID: 1847614, DOI: 10.1002/ana.410290109.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBase SequenceBlotting, SouthernChild, PreschoolClone CellsDNA ProbesFemaleGene Rearrangement, beta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorHumansMaleMiddle AgedMolecular Sequence DataMultiple SclerosisPhenotypePolymerase Chain ReactionT-LymphocytesConceptsT cell populationsT cell clonesCerebrospinal fluidMultiple sclerosisT cellsT cell receptor Vβ usageNeurological diseasesOligoclonal T-cell populationsT cell receptor V beta genesOligoclonal T lymphocytesOligoclonal T cellsSame T cell receptorBlood of patientsNormal control subjectsT cell receptor beta chainProgenitor T cellsT cell receptorIndividual T cellsGamma chain geneImmune compartmentVβ usageControl subjectsReceptor beta chainT lymphocytesPatients
1987
Activated T-Cells and Antigen Reactivity in the Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis
Hafler D, Weiner H. Activated T-Cells and Antigen Reactivity in the Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis. 1987, 261-272. DOI: 10.1007/978-1-4899-5348-3_31.Peer-Reviewed Original Research
1985
Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis
Hafler D, Buchsbaum M, Johnson D, Weiner H. Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis. Annals Of Neurology 1985, 18: 451-458. PMID: 2416267, DOI: 10.1002/ana.410180407.Peer-Reviewed Original ResearchConceptsMultiple sclerosisBlood of patientsT cellsMyelin basic proteinCerebrospinal fluid lymphocytesT-cell abnormalitiesCSF of patientsAntigen-specific cellsIndividual T cellsBasic proteinSuppressor cellsViral meningoencephalitisStimulating lymphocytesInterleukin-2Antigen reactivityCell abnormalitiesCerebrospinal fluidSingle cell clonal analysisPatientsT8 populationWhite matterBloodCSFSclerosisLymphocytesIn Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis
Hafler D, Fox D, Manning M, Schlossman S, Reinherz E, Weiner H. In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis. New England Journal Of Medicine 1985, 312: 1405-1411. PMID: 2985995, DOI: 10.1056/nejm198505303122201.Peer-Reviewed Original ResearchConceptsProgressive multiple sclerosisMultiple sclerosisInterleukin-2 receptorNervous system diseasesNeurologic diseaseSpinal fluidPeripheral bloodSystem diseasesCerebrospinal fluidInflammatory central nervous system diseasesCentral nervous system diseaseSystemic immune activationInflammatory neurologic diseasesPeripheral blood lymphocytesBlood of patientsActivated T lymphocytesAbnormal immunologic activityCent of lymphocytesCent of cellsT cell activationImmune activationT cellsT lymphocytesImmunologic activityNormal controls