2018
Regulatory T Cells: From Discovery to Autoimmunity
Kitz A, Singer E, Hafler D. Regulatory T Cells: From Discovery to Autoimmunity. Cold Spring Harbor Perspectives In Medicine 2018, 8: a029041. PMID: 29311129, PMCID: PMC6280708, DOI: 10.1101/cshperspect.a029041.Peer-Reviewed Original ResearchConceptsAutoreactive T cellsT cellsMultiple sclerosisEffector-like T cellsInterferon γ secretionEffector T cellsRegulatory T cellsTreg cell functionT-bet expressionCentral nervous systemT cell activationFunctional TregsΓ secretionProinflammatory cytokinesVitamin DAutoimmune diseasesGenetic predispositionNervous systemLoss of functionReduced suppressionConsistent findingCell functionDisease developmentActivationCells
1998
Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cells
Mandelboim O, Kent S, Davis D, Wilson S, Okazaki T, Jackson R, Hafler D, Strominger J. Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 3798-3803. PMID: 9520447, PMCID: PMC19917, DOI: 10.1073/pnas.95.7.3798.Peer-Reviewed Original ResearchConceptsNatural killer cell activating receptorsT cellsNK cellsInterferon γ secretionSubset of CD8Target cellsHuman class I major histocompatibility complex (MHC) moleculesNatural killer cellsInterferon-gamma secretionGammadelta T cellsMajor histocompatibility complex moleculesAlphabeta T cellsClass I MHC moleculesClass I major histocompatibility complex moleculesTypes of lymphocytesMHC class IHistocompatibility complex moleculesI MHC moleculesT cell receptorEnhancement of proliferationΓ secretionGamma secretionNatural killerKiller cellsActivating receptors