1999
Constitutive Calcium-independent Release of Toxoplasma gondii Dense Granules Occurs through the NSF/SNAP/SNARE/Rab Machinery*
Chaturvedi S, Qi H, Coleman D, Rodriguez A, Hanson P, Striepen B, Roos D, Joiner K. Constitutive Calcium-independent Release of Toxoplasma gondii Dense Granules Occurs through the NSF/SNAP/SNARE/Rab Machinery*. Journal Of Biological Chemistry 1999, 274: 2424-2431. PMID: 9891012, DOI: 10.1074/jbc.274.4.2424.Peer-Reviewed Original ResearchConceptsN-ethylmaleimide-sensitive fusion proteinDense matrix granulesDense granulesBeta-lactamase secretionMammalian homologueDissociation inhibitorAbsence of ATPPathogenic protozoan parasitesCalcium-independent fashionPermeabilized parasitesFusion proteinProtein componentsProtozoan parasiteCalcium-independent releaseDense granule releaseParasitesMachineryProteinN-ethylmaleimideGuanosine 5'Matrix granulesGranule releaseToxoplasma gondiiGranulesHomologues
1996
Identification of a Cellular Protein That Specifically Interacts with the Essential Cysteine Region of the HIV-1 Tat Transactivator
KAMINE J, ELANGOVAN B, SUBRAMANIAN T, COLEMAN D, CHINNADURAI G. Identification of a Cellular Protein That Specifically Interacts with the Essential Cysteine Region of the HIV-1 Tat Transactivator. Virology 1996, 216: 357-366. PMID: 8607265, DOI: 10.1006/viro.1996.0071.Peer-Reviewed Original ResearchMeSH KeywordsAcetyltransferasesAmino Acid SequenceBase SequenceCloning, MolecularConserved SequenceCysteineDNA, ComplementaryEscherichia coliGene Expression Regulation, ViralGene Products, tatHeLa CellsHistone AcetyltransferasesHIV-1HumansLysine Acetyltransferase 5Molecular Sequence DataPoint MutationPromoter Regions, GeneticProtein BindingProteinsSaccharomyces cerevisiaeTat Gene Products, Human Immunodeficiency VirusConceptsHIV gene expressionGene expressionN-terminal 31 amino acidsEssential cysteine residueFull-length cDNATat activation domainHIV-1 Tat transactivatorPartial cDNA cloneHIV-1 promoterActivation domainCellular proteinsTAT activityAbolishes interactionCysteine regionCDNA clonesCellular cofactorsCysteine residuesTransient expressionTat transactivationTat transactivatorHIV-1 TatAmino acidsInteractive cloningProteinPromoter
1994
Analysis of Egr-1 protein induction in murine peritoneal macrophages treated with granulocyte-macrophage colony-stimulating factor.
Li C, Mitchell D, Coleman D. Analysis of Egr-1 protein induction in murine peritoneal macrophages treated with granulocyte-macrophage colony-stimulating factor. The Yale Journal Of Biology And Medicine 1994, 67: 269-76. PMID: 8579643, PMCID: PMC2588905.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBlotting, WesternCell DivisionDNA-Binding ProteinsDose-Response Relationship, DrugEarly Growth Response Protein 1Granulocyte-Macrophage Colony-Stimulating FactorImmediate-Early ProteinsMacrophages, PeritonealMiceMolecular Sequence DataThioglycolatesTranscription FactorsConceptsEgr-1 proteinMurine peritoneal macrophagesEarly growth response gene-1Macrophage proliferationGranulocyte-macrophage colony-stimulating factorResponse gene-1Egr-1 mRNAProtein speciesColony-stimulating factorGM-CSFPathogen invasionWestern blot analysisGene 1Stimulation of macrophagesMacrophage differentiationPeritoneal macrophagesProtein inductionProteinBlot analysisTranscriptionProliferationGM-CSF inductionInductionMacrophagesPhysiologic circumstances
1991
Conversion of a human B cell lymphoma line by Epstein-Barr virus is associated with increased tyrosine phosphorylation of a 50 kilodalton cytosolic protein
Lacy J, Bartiss A, Coleman D. Conversion of a human B cell lymphoma line by Epstein-Barr virus is associated with increased tyrosine phosphorylation of a 50 kilodalton cytosolic protein. Virus Research 1991, 20: 85-96. PMID: 1656626, DOI: 10.1016/0168-1702(91)90063-2.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusB cellsHuman B cellsB-cell lymphoma linePresence of EBVLymphoma linesProtein tyrosine phosphorylationEBV infectionHuman B cell lymphoma lineTyrosine phosphorylationB lymphocytesImmortalized lymphoblastoid cellsBiochemical changesLymphoblastoid cellsInfectionEndogenous tyrosine kinasesContinuous proliferationCytosolic proteinsTyrosine kinaseVirusCellsPhosphorylationPhosphotyrosine antibodiesLymphocytesProtein