2014
Cerebral cavernous malformation proteins at a glance
Draheim KM, Fisher OS, Boggon TJ, Calderwood DA. Cerebral cavernous malformation proteins at a glance. Journal Of Cell Science 2014, 127: 701-707. PMID: 24481819, PMCID: PMC3924200, DOI: 10.1242/jcs.138388.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosis Regulatory ProteinsCapillary PermeabilityCarrier ProteinsCentral Nervous System NeoplasmsHemangioma, Cavernous, Central Nervous SystemHumansKRIT1 ProteinMembrane ProteinsMicrotubule-Associated ProteinsNeoplasm ProteinsProto-Oncogene ProteinsRho GTP-Binding ProteinsSignal TransductionConceptsAdaptor proteinCerebral Cavernous Malformation ProteinsMulti-domain adaptor proteinBasic cellular processesProtein-protein interactionsCerebral cavernous malformationsAccompanying posterGlance articleCCM proteinsCellular processesProtein functionCellular phenotypesTrimeric complexFunction mutationsCell adhesionCell scienceProteinLeaky blood vesselsFocal neurological defectsCurrent understandingNeurological defectsCytoskeletalGenesPDCD10KRIT1
2003
The Kindler Syndrome Protein Is Regulated by Transforming Growth Factor-β and Involved in Integrin-mediated Adhesion*
Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC. The Kindler Syndrome Protein Is Regulated by Transforming Growth Factor-β and Involved in Integrin-mediated Adhesion*. Journal Of Biological Chemistry 2003, 279: 6824-6833. PMID: 14634021, DOI: 10.1074/jbc.m307978200.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid SequenceBlotting, NorthernBlotting, WesternCell AdhesionCell LineCell MovementCytoplasmCytoskeletonDisease ProgressionDNA, ComplementaryExtracellular Matrix ProteinsFluorescent Antibody Technique, IndirectGene Expression RegulationHumansIntegrin beta1Integrin beta3IntegrinsMembrane ProteinsModels, MolecularMolecular Sequence DataMutationNeoplasm ProteinsOligonucleotide Array Sequence AnalysisProtein BindingProtein Structure, TertiaryRNARNA, MessengerRNA, Small InterferingSequence Homology, Amino AcidTime FactorsTransfectionTransforming Growth Factor betaUp-RegulationConceptsHuman mammary epithelial cellsCytoplasmic domainIntegrin cytoplasmic domainBeta3 integrin cytoplasmic domainsCDNA microarray analysisTGF-beta stimulationNormal cell spreadingMammary epithelial cellsSyndrome proteinFERM domainFocal adhesionsTranscriptional profilesProtein abundanceCritical residuesMicroarray analysisCell spreadingGene leadTalin-FERMCell migrationCancer progressionIntegrin betaGenesCell processesAutosomal recessive genodermatosisEpithelial cells