2012
Kisspeptin Inhibits High-Voltage Activated Ca2+ Channels in GnRH Neurons via Multiple Ca2+ Influx and Release Pathways
Zhang XB, Spergel DJ. Kisspeptin Inhibits High-Voltage Activated Ca2+ Channels in GnRH Neurons via Multiple Ca2+ Influx and Release Pathways. Neuroendocrinology 2012, 96: 68-80. PMID: 22343183, DOI: 10.1159/000335985.Peer-Reviewed Original ResearchConceptsGnRH neuronsGnRH-green fluorescent protein transgenic miceG protein-coupled receptor 54Phospholipase C inhibitor edelfosineWhole-cell patch-clamp recordingsGonadotropin-releasing hormone (GnRH) secretionCanonical transient receptor potential (TRPC) channelsTransient receptor potential channelsRyR agonist caffeinePatch-clamp recordingsChelation of intracellularVGCC activityReceptor 54Kisspeptin-10Hormone secretionPeptide 234KP-10Antagonist caffeineBrain slicesSubsequent fertilityTransgenic miceTRPC channelsNeuronsDependent inhibitionCytoplasmic free
1995
Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells.
Bagnato A, Tecce R, Moretti C, Di Castro V, Spergel D, Catt K. Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells. Clinical Cancer Research 1995, 1: 1059-66. PMID: 9816080.Peer-Reviewed Original ResearchConceptsOvarian carcinoma cellsHuman ovarian carcinoma cellsET-1ETA receptorsEndothelin-1Carcinoma cellsTumor cellsCell linesGrowth factorCertain ovarian tumorsET-1 participatesReceptor-mediated actionsOVCA 433 cellsOvarian tumor cell linesCalcium signalingDose-dependent increaseRadioligand binding studiesOvarian tumor cellsAutocrine growth factorOvarian cancer cellsSites/cellBasal growth rateAuthentic ET-1BQ-123ET receptors